J4

• 基础研究 • 上一篇    下一篇

兔人工晶体植入围手术期TNF-α及IL-8检测的临床意义

韩丽娜1,2,宋 鄂1,董 宇1,董 倩3,于 军1   

  1. 1. 吉林大学第一医院眼科,吉林 长春 130021;2. 中国人民解放军总医院激光科,北京100853;3. 吉林省妇幼保健院眼科,吉林 长春 130021
  • 收稿日期:2003-03-26 修回日期:1900-01-01 出版日期:2004-01-28 发布日期:2004-01-28

Clinical signifcance of detection of TNF-α and IL-8in rabbits after IOL implantation

HAN Li-na1,2, SONG E1, DONG Yu1, DONG Qian3 ,YU Jun1   

  1. 1. Department of Ophthalmology, First Hospital,Jilin University, Changchun 130021,China;2. Department of Laser,No.301 Hospital of PLA,Beijing 100853,China;3. Department ofOphthalmology, Matemal and Child Health Hospital of Jilin Province,Changchun 130021,China
  • Received:2003-03-26 Revised:1900-01-01 Online:2004-01-28 Published:2004-01-28

摘要: 目的:探讨肿瘤坏死因子α(TNF-α)及白细胞介素8(IL-8)在人工晶体植入术后的变化及其临床意义。方法:采用放射免疫法对24例晶体囊外摘除(ECCE)、后房型人工晶体植入术后(PCIOL)家兔和20例正常家兔进行血浆和房水TNF-α、IL-8测定。结果:24例家兔术后血浆和房水TNF-α、IL-8均升高,且呈动态变化,与术后恢复情况相关。结论:血浆和房水TNF-α、IL-8在ECCE、PCIOL植入术后的动态变化可作为监测术后恢复情况、估计病人预后及转归的实验室指标。

关键词: 血液, 白细胞介素8, 血液, 晶体, 人工

Abstract: Objective To investigate the clinical significance of the changes of tumor necrosis factor α(TNF-α) and interleukin-8 (IL-8) in rabbits after extracapsular extraction (ECCE) and posterior chamber intraocular lens (PCIOL) implantation. Methods The level of TNF-α and IL-8 from the samples of 4 mL venous blood and 300 μL aquous humor were determined by radioimmunoassy in 24 rabbits with intraocular lens (IOL) implantation and 20 normal rabbits at the same time with the operation group. Results The levels of TNF-α and IL-8 in serum and aqueous humour after operation were increased in 24 rabbits and which related to postoperative recovery. Conclusion The levels of TNF-α and IL-8 in rabbits after ECCE and PCIOL implantation may be indexes to judge the postoperative recovery and to predict progress.

Key words: blood, interleukin-8, blood, lenses, intraocular

中图分类号: 

  • R776