关键词: 疾病模型, 动物

Abstract: Objective To investigate the method to establish fatty liver model of rats. Methods The rats were fed on a diet deficient in choline and amino acid (methionine in chief) and fatty liver models were established successfully. The changes of rat portal vein pressure, ratio of liver weigh/body weigh, and pathological structure of liver were observed. Results Fourteen days later, much more fatty droplets were accumulated in the livers of rats, more than two thirds of liver cells had fatty droplets accumulation after twenty-one and twenty-eight days. The form of fatty liver cells were irregular, liver sinus became narrow and irregular; portal vein pressure of the fatty liver was higher than that of normal one, weights of the liver and body were both lighter than that of normal one. Conclusion This method is effective and economical to establish fatty liver model of rat in short time.

Key words: animal