关键词: 周围神经, 神经再生, 雪旺氏细胞

Abstract: Objective To observe the role of platelet-derived growth factor-B (PDGF-B) in the regeneration of peripheral nerve by studying its expression on injured rat sciatic nerves. Methods The rat sciatic nerves cut and crush-injured models were established, the expressions of PDGF-B on both injured nerves were detected by immunohistochemistry technique. Results The expressions of PDGF-B were increased in proximal nerve segments and regenerating axons in both models. Soon after both types of injury, considerable amounts of PDGF-B accumulated in Schwann cells in distal segments of both models. With restoration of the axon-Schwann cells relationship in the crush model, levels of PDGF-B tended to decrease, eventually returned to normal. In the cut model the relationship can not be restored, the PDGF-B was decreased to a very low level. Conclusion The increased expression of PDGF-B after sciatic nerve injury may contribute to peripheral nerve regeneration.

Key words: peripheral nerve, nerve regeneration, Schwann cells