关键词: 糖皮质激素, 肾病综合征, 综合分析

Abstract: Objective To assess the therapeutic effect of tripterygium glycosides(TG) and glucocorticoid(GC) for nephritic syndrome(NS). Methods Randomized controlled trials(RCT) or clinical controlled trials(CCT) with TG and GC for treatment of NS as treatment group and GC as control group were applied for the systemic review. According to the requirements of Cochrane systematic review,a thorough literature search was performed among PubMed,Cochrane library,CBMdisc,CNKI,Wanfang Database and relevant medical journals in China.Two qualified reviewers reviewed the original articles,extracting data and evaluating the quality independently.With RevMan 4.2 software,a Meta-analysis was performed on 9 papers which met the inclusion criteria. Results The literatures of remission and recurrence rate had homogeneity.Compared with control group,the incorporation remission rate in treatment group was higher(OR＝2.61，95%CI 1.37－4.97),but the incorporation recurrence rate after six months had significant difference(OR =0.18，95%CI 0.09-0.36).Funnel plots were nearly symmetry. Conclusion TG and GC may become a prospect therapy for NS.Their definite effects for NS will be further confirmed by multiple-center,large-sample RCT.

Key words: glucocorticoid, nephritic syndrome, Meta-analysis