关键词: 子宫内膜异位症, 皮质醇

Abstract: Objective To investigate the clinic curative effects,serum cortisol and ovarian function after treated with low-dose mifepristone following conservative surgery in recurrent endometriosis.Methods One hundred twenty-six patients with recurrent endometriosis after abdominoscope diagnosis were divided into M and D groups,the patients in group M (n=72)were treated orally with mifepristone and group D(n=54) with danazol,the symptoms，signs，ovarian function and changes in blood cortisol 3 months after treatment were observed. Results The differences　 of remission rates after treatment on symptoms, dysmenorrhea,hypogastralgia during non menstrual period,sexual intercourse pain,pelvic cavity tenderness,rear excavation tuberosity,womb movement restriction,aberrant ovary cyst size between two groups were not significant (P>0.05).After treatment,blood serum E₂ level in group M was (74.18±22.32) pmol•L^-1,whereas that in group D was (24.96±3.94)pmol•L^-1,there was significant difference（P<0.01).The differences of blood serum cortisol level between two groups had no significant difference (P>0.05). Conclusion Clinical symptoms of patients with recurrent endometriosis in two groups are improved.Serum E₂ level in group M remains in the follicular phase,but group D declines to postmenopausal range.Mifepristone does not result in lack of estrogen,ovulation recovers rapidly after treatment in group M compared with group D.Mifepristone and danazol have not obvious impact on blood serum cortisol.

Key words: endometriosis, serum cortisol