生物降解材料己内酯/还氧乙烷共聚物的生物相容性及体内外降解

生物降解材料己内酯/还氧乙烷共聚物的生物相容性及体内外降解

侯宇川¹，王春喜¹，李娜²

1. 吉林大学第一医院泌尿外科，吉林长春 130021；2. 吉林省肿瘤医院泌尿外科，吉林长春 130012

收稿日期:2003-05-12 修回日期:1900-01-01 出版日期:2004-05-28 发布日期:2004-05-28

Biocompatibility and biodegradation of poly (caprolactone-b-ethylene oxide) in vivo and in vitro

HOU Yu-chuan¹,WANG Chun-xi¹,LI Na²

1.Department of Urology，First Hospital, Jilin University, Changchun 130021, China;2. Department of Urology, Oncological Hospital of Jilin Province,Changchun 130012,China

Received:2003-05-12 Revised:1900-01-01 Online:2004-05-28 Published:2004-05-28

摘要/Abstract

摘要： 目的：探讨国产生物降解泌尿系支架材料己内酯/还氧乙烷共聚物（PCL-EO）的生物相容性及体内、体外降解特性。方法：将PCL-EO试件埋植在Wistar大鼠脊柱两侧肌肉内或浸泡于流动的尿液中，分别于2、4、6、8、10、12、14及16周取出，通过组织病理学切片研究材料周围组织反应，利用扫描电镜检查和分子量、重量检测以了解PCL-EO在体内、体外的降解情况。结果：PCL-EO材料在16周内可降解为随尿液流动的细小颗粒。材料的体内、体外降解趋势相同，体内降解速度略快于体外降解。埋植材料周围肌肉组织无脓肿形成和组织坏死发生，局部组织反应为非细菌性炎症反应。结论:PCL-EO材料生物相容性良好，降解时间适宜，适用于制备泌尿系支架，可进一步临床研究开发。

关键词: 生物降解, 泌尿道, 支架

Abstract: Objective To study the biocompatibility and biodegradation characteristics of poly(caprolactone-b-ethylene oxide) (PCL-EO), a kind of biodegradable material, used for urological stent in vivo and in vitro. Methods Pellets made from PCL-EO were implanted in the dorsal muscle of Wistar rats or dipped into flowing urine. Tissue blocks surrounding the biomaterials and the PCL-EO pellets were took out after 2, 4, 6, 8, 10, 12, 14 and 16 weeks， respectively. Histological study was taken to investigate the tissue reaction of the material and evaluate its biocompatibility. Scanning electron microscopy (SEM) and measurement of molecular weight and gravity were used to make out the biodegradation characteristics of PCL-EO both in vivo and in vitro. Results The PCL-EO test pieces degraded into small particles that could be excreted with the urine flow after 16 weeks. The biodegradation pattern in vivo was similar to that in vitro. There was no abscess formation and tissue necrosis surrounding the implanted materials. Non-infectious reactions due to materials implanted were observed. Conclusion The biodegradable material PCL-EO has good biocompatibility and appropriate biodegradation characteristics and will meet the request for urological stent.

Key words: biodegradation, urinary tract, stents

中图分类号:

R318

侯宇川，王春喜，李娜. 生物降解材料己内酯/还氧乙烷共聚物的生物相容性及体内外降解[J]. J4, 2004, 30(3): 362-365.

HOU Yu-chuan,WANG Chun-xi,LI Na. Biocompatibility and biodegradation of poly (caprolactone-b-ethylene oxide) in vivo and in vitro[J]. J4, 2004, 30(3): 362-365.

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