关键词: 吸入糖皮质激素, 有效性, 安全性

Abstract: Objective To assess the efficacy and safety of inhaled corticosteoids for childhood asthma．Methods According to the requirements of Cochrane systematic review,a thorough literature search was performed among PubMed，China National Knowledge Infrastructure，Wanfang Date，and so on.With RevMan 4.2 software,a Meta-analysis was performed on a total of 1 994 children involved in 19 papers which met with the inclusion criteria．Results The literatures of total effective rates had homogenicity.In comparison of the treatment groups and the control，the incorporation was statistically significant［OR＝8.27，95%CI(5.20, 13.16)］．The literatures of serum osteocalcin levels after the treament for 6 and 12 months and growth rates had heterogeneity，and that of serum ACTH levels had homogenicity．Comparing the treatment group with the control group，the incorporation of the growth rates had statistical difference，while the other three incorporations did not．Sensitivity analysis showed that the results of total effective rates，serum osteocalcin levels after the treament for 12 months，growth rates and serum ACTH levels were stable and reliable，but that of serum osteocalcin levels after 6 months treament required further approach．The results of publication bias showed that the impact was small，and the results was reliable．〖WTFZ〗Conclusion The clinical evidences available so far indicats that the treatment of childhood asthma with inhaled corticosteroids is safe and efective，although rigorous designe and large sample size randomized double-blind clinical trials are required to further analysis for more stable and reliable results．

Key words: efficacy, safety