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CT定量测量老年2型糖尿病患者骨密度变化及其与血糖水平的相关性分析

王桂芝1,乔俊华2,梁 萍1,刘纯岩2   

  1. (1.吉林大学中日联谊医院放射线科,吉林 长春 130033;2.吉林大学第二医院放射线科,吉林 长春 130041)
  • 收稿日期:2008-03-27 修回日期:1900-01-01 出版日期:2008-11-28 发布日期:2008-11-28
  • 通讯作者: 王桂芝

Correlation analysis between bone density measured by quantitative CT and blood sugar level of aged patients with non-insulin-dependent diabetes mellitus

WANG Gui-zhi1,QIAO Jun-hua2,LIANG Ping1,LIU Chun-yan2   

  1. (1.Department of Radiology,China-Japan Union Hospital,Jilin University,Changchun 130033,China; 2.Department of Radiology,Second Hospital,Jilin University,Changchun 130041,China)
  • Received:2008-03-27 Revised:1900-01-01 Online:2008-11-28 Published:2008-11-28
  • Contact: WANG Gui-zhi

摘要: 目的:分析老年2型糖尿病患者骨密度的变化及其与血糖水平的相关性,探讨血糖水平高低对其骨密度的影响。方法:采用定量CT对160例老年2型糖尿病患者(血糖及糖化血红蛋白控制正常组80例,血糖及糖化血红蛋白异常增高组80例)及健康老年人80例进行腰椎骨密度测定,检测血糖水平并分析其相关性;比较糖尿病高血糖组、糖尿病血糖控制正常组和健康老年对照组的骨质疏松的发生率。结果:糖尿病高血糖组骨密度低于对照组及糖尿病血糖控制正常组(P<0.05);糖尿病高血糖组骨质疏松症发生率明显高于对照组及糖尿病血糖控制正常组(P<0.05);老年2型糖尿病患者的骨密度与血糖水平呈负相关关系(老年男性组:r=-0.738 2,P=0.001 3;老年女性组:r=-0.834 3,P=0.000 7)。结论:老年2型糖尿病患者的血糖水平影响骨密度,血糖水平越高,骨密度越低;血糖控制不佳的老年2型糖尿病患者更易患骨质疏松症。

关键词: 非胰岛素依赖型, 血糖, 体层摄影术, X线计算机, 骨密度, 骨质疏松症

Abstract: To approach the correlation between the bone density measured by quantitative CT and the blood sugar level of the aged patients with non-insulin-dependent diabetes mellitus,and observe the effects of the blood sugar level on the bone density.Methods The lumbar bone densities and the blood sugar levels of 160 aged patients with non-insulin-dependent diabetes mellitus (hyperglycemia group 80 cases,euglycemia group 80 cases ) and the healthy aged people (80 cases) were detected by quantitative CT and serum biochemical detection; the correlation between the blood sugar level and the bone density and the osteoporosis occurrence status of aged people in various groups were analyzed.Results The bone density in the non-insulin-dependent diabetes and hyperglycemia group was lower than those in normal(control) group and non-insulin-dependent diabetes and euglycemia group (P<0.05); the morbility of osteoporosis in the non-insulin-dependent diabetes and hyperglycemia group was higher than those in normal(control) group and non-insulin-dependent diabetes and euglycemia group (P<0.05);negative correlation was found between the bone density and the blood sugar level (aged male group:r=-0.7382,P=0.0013;aged female group:r=-0.8343,P=0.0007).Conclusion The blood sugar level affects the bone density of the aged patients with non-insulin-dependent diabetes mellitus;the higher the blood sugar level,the lower the bone density.The non-insulin-dependent diabetes aged patients with hyperglycemia have the liability of osteoporosis.

Key words: non-insulin-dependent, blood glucose, tomography, X-ray computed, bone density, osteoporosis

中图分类号: 

  • R587.1