关键词: 非小细胞肺, Stat3, CyclinD_1<, sub>, 增殖细胞核抗原, 肿瘤侵润, 肿瘤转移, 免疫组织化学

Abstract: Objective To investigate the expressions of Stat3, CyclinD₁ and proliferating cell nuclear antigen (PCNA) in non-small cell lung cancer (NSCLC),and analyze their relationships with carcinogenesis and progression of NSCLC. Methods SP immunohistochemistry was used to detect the expressions of Stat3, CyclinD₁ and PCNA in 45 cases of NSCLC. Results The positive rate of Stat3 was 71.1 % in NSCLC. The expression intensities of Stat3 was not associated with different tumor sizes and histological type, but it was associated with the expression intensities of CyclinD₁ and PCNA （r＝0.531, P<0.01；r＝0.618, P<0.01）and it was re lated to histological grade and lymph node metastasis（P<0.05）.Conclusion The expression of Stat3 is abnormal in NSCLC. Stat3 may involve in regulation of CyclinD₁ in NSCLC and accelerate proliferation of NSCLC, it may play an important role in generation of NSCLC.

Key words: non-small cell lung, Stat3, CyclinD_1<, sub>, proliferating cell nuclear antigen, neoplasm invasiveness, neoplasm metastasis, immunohistochemistry