慢性肺心病患者生命质量与临床客观指标的关系

J4 ›› 2012, Vol. 38 ›› Issue (3): 580-585.

慢性肺心病患者生命质量与临床客观指标的关系

李娜¹|赵芝焕¹|万崇华²

1. |昆明医科大学第一附属医院皮肤科|云南昆明 650032；2.昆明医科大学公共卫生学院|云南昆明650000

收稿日期:2011-11-22 出版日期:2012-05-28 发布日期:2012-05-28
通讯作者: 万崇华(Tel:0871-5324888,E-mail:wanchh@hotmail.com) E-mail:wanchh@hotmail.com
作者简介:李娜(1980-)|女|云南省建水县人|主管护师|医学硕士|主要从事慢性疾病生命质量的研究。
基金资助:
国家自然科学基金资助课题（30360092,30860248）。

Relationships between quality of life and clinical indicators of patients with chronic pulmonary heart disease

LI Na¹|ZHAO Zhi-huan¹|WAN Chong-hua²

1.Department of Dermatology,First Affiliated Hospital,Kunming Medical University,Kunming 650032,China;2.School of |Public Health,Kunming Medical University,Kunming 650032,China

Received:2011-11-22 Online:2012-05-28 Published:2012-05-28

摘要/Abstract

摘要：

目的: 分析慢性肺心病（CPHD）患者生命质量(QOL)与临床客观指标之间的关系，探讨CPHD患者QOL得分变化的临床意义。方法: 采用CPHD患者QOL测定量表QLICD-CPHD（V2.0）测试版。选择CPHD急性加重期患者141例，分别收集患者在入院当天和出院日数据2次。分析患者一般情况、临床客观指标与QOL得分的关系。结果:QOL与丙氨酸氨基转移酶、天门冬氨酸氨基转移酶、尿素、血小板计数、PaCO2和体温呈负相关关系，与总蛋白、血钾、白细胞数、中性粒细胞群绝对值、红细胞计数、PO2和肺功能指标呈正相关关系。肺功能是QOL得分变化的影响因素，其中躯体功能领域的影响指标有FVC、FEV1和EV1/FVC；心理功能领域的影响指标有FEV1、EV1/FVC和PEF；社会功能领域的影响指标有PEF和FVC；特异模块领域的影响指标有FVC、FEV1、EV1/FVC和PEF；量表总分的影响指标有FVC、FEV1、PEF和EV1/FVC。与肺功能分级结合分析QOL得分变化的95%可信区间得出躯体功能领域得分最小变化5.25，社会功能领域最小变化3.27，心理功能领域得分最小变化2.91，特异模块领域得分最小变化7.62，总量表得分最小变化10.85，具有临床意义。结论：QOL得分的变化可以反映CPHD患者临床病情变化的程度和情况。

关键词: 生命质量；慢性肺源性心脏病；临床指标；临床最小显著性差异

Abstract:

Objective To analyze the relationships between quality of life (QOL) and socio-demographic and clinical characteristics of patients with pulmonary heart disease(CPHD),and to discuss the clinical significance of the QOL score changes.Methods The survey was conducted in 141 CPDH patients who were in the acute exacerbation.Using the QLICD-CPHD（V2.0）which was a QOL scale for CPHD patients to detect the data.The data was assessed at the time of patients’ admission and dischange to the hospital.The relationships between QOL and socio-demographic and clinical characteristics were analyzed by statistical methods.Results QOL was negatively correlated with the alanine aminotransferase,the aspartate amino transferase,the urea,the blood platelet count,the PaCO2 and the body temperature;and QOL was positively correlated with the total protein,the kalium,the leukocyte number,the neutrophil absolute value,the red blood cell count,the PO2 and the lung functional parameters.Lung function was the influence factor of the QOL.The influence factors of the body function included FVC,FEV1, EV1/FVC and PEF;the influence factors of the psychological function included FEV1,EV1/FVC and PEF;the influence factors of the social function included PEF and FVC;the influence factors of the specific module included FVC,FEV1,EV1/FVC and PEF;the influence factors of the total scale scores included FVC,FEV1,PEF and EV1/FVC.The 95% confidence interval of QOL was analyzed by combinating with the lung functional classification,then the clinical significances were revealed when the minimal changes of scores were 5.25 in physical function,3.27 in social function,2.91 in psychological function,7.62 in specific module and 10.85 in the overall.Conclusion The change of QOL score can reflect the clinical degree and condition of CPHD patients.

Key words: quality of life；chronic pulmonary heart disease；clinical objective indicator；minimal clinically importance difference

中图分类号:

Q563

李娜|赵芝焕|万崇华. 慢性肺心病患者生命质量与临床客观指标的关系[J]. J4, 2012, 38(3): 580-585.

LI Na|ZHAO Zhi-huan|WAN Chong-hua. Relationships between quality of life and clinical indicators of patients with chronic pulmonary heart disease[J]. J4, 2012, 38(3): 580-585.