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短暂性脑缺血患者血清C反应蛋白水平与脑血栓形成的关系

常 颖,韩雪梅,邢 影, 杨 宏   

  1. 吉林大学中日联谊医院神经内科,吉林 长春  130033
  • 收稿日期:2007-07-11 修回日期:1900-01-01 出版日期:2008-05-28 发布日期:2008-05-28
  • 通讯作者: 杨 宏

Relationship between levels of serum CRP and cerebral thrombosisin patients with transient ischemia attack

CHANG Ying,HAN Xue-mei,XING Ying,YANG Hong   

  1. Department of Neurology,China-Japan Union Hospital,Jilin University,Changchun,130033,China
  • Received:2007-07-11 Revised:1900-01-01 Online:2008-05-28 Published:2008-05-28
  • Contact: YANG Hong

摘要: 目的:观察短暂性脑缺血发作(TIA)患者血清C反应蛋白 (CRP) 的水平,探讨CRP与其他危险因素的关系。方法:102例TIA患者根据病程分为两组,即在2周内进展为脑梗塞者为进展组(n= 40),未继续进展者为未进展组(n=62)。所有患者在入院24 h内首次测定血清CRP水平,同时测血压(BP)、血糖(BS),纤维蛋白原(FIB)、血脂参数如总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白(HDL-L)、低密度脂蛋白(LDL-L)。67例健康体检者作为对照组。CRP分别与上述8个指标进行相关性分析。结果:①TIA组的CRP血清水平高于正常对照组(P<0.05),且进展组高于未进展组(P<0.05)。②相关性分析显示,CRP与BP、BS、TG、FIB均呈显著性正相关关系(P<0.01,γ值分别是0.517、0.439、0.533、0.406)。结论:CRP是评价TIA患者短期内是否进展为完全性卒中的一个非特异性的、新的血清学指标;CRP血清水平越高,TIA发展为脑梗塞的可能性越大。

关键词: 短暂性, 脑梗塞, C反应蛋白质

Abstract: Abstract:Objective To observe the serum level of C-reactive protein(CRP) in transient ischemic attack(TIA) patients,and to assess the correlation between CRP and other dangerous factors of cerebral infarction.Methods 102  TIA patients were divided into two groups: TIA deteriorated into cerebral infarction in two weeks (group A,n=40) and TIA could be relieved in two weeks (group B,n=62).Many factors were measured within 24 h,such as CRP,BP,BS,FIB,TC,TG,HDL-L, and LDL-L.67 healthy subjects were usded as control group.Relative analysis was performed between CRP and 8 parameters mentioned above.Results ①The serum CRP level of TIA patients was higher than that of healthy controls (P<0.05).It was also higher in group A than that in group B (P<0.05).②The correlative analysis demonstrated that the serum CRP level had obviously positive relationships with BP,BS,FIB and TG(P<0.01),the γ  values were 0.517,0.439,0.533,and 0.406, respectively.Conclusion CRP is a non-differential,but very important new serum symbol to evaluate whether TIA evolves to cerebral infarction in a short period of time.The higher serum CRP level is,the more probably TIA evolves to complete stroke.

Key words: transient, brain infarction, C-reactive protein

中图分类号: 

  • R732.3