关键词: 药理学, 糖尿病, 实验性, 血液, 胰岛素抵抗

Abstract: Objective To study the effects of Panaxadiol Saponins (PDS) on glycemia, lipid and the improvement of insulin resistance (IR) in type 2 diabetes mellitus rats (T2DM). Methods Rats were randomly divided into normal group, model group, PDS 35,70 and 140 mg•kg^-1 groups and metformin group. Rats were fed by high fat diet for 10 d and injected with small dose of streptozotocin(STZ) 55 mg•kg^-1. Rats with plasma glucose over 11.1 mmol•L^-1we re assigned to T2DM model group,continually fed with PDS 35,70,140 mg•kg^-1•d-1 for 4 weeks and the values of fasting blood glucose (FBG) were assayed every week . Then FBG, Ins, C-peptide, FFA, TC, TG, HDL-c, LDL-c, MDA content and SOD activity were measured after 4 weeks. Results After treated with PDS for 4 weeks, the FBG in PDS 70, 140 mg•kg^-1 and metformin groups decreased significantly compared with normal group from the third week to the forth week (P<0.01); the liver glycogen　content was higher than that in model control (P<0.05 or P<0.01), the leve ls of TC, TG, FFA, TC/HDL-c, LDL-c/HDL-c and MDA were lower than those in model control (P<0.05 or P<0.01) . SOD activity, C-peptide content and ISI increased significantly (P<0.05 or P<0.01), while LDL-c, HDL-c changed little (P>0.05). Conclusion PDS could decrease the blood glucose, improve the disorder of the serum lipid and insulin sensitivity in T2DM rats.

Key words: pharmacology, diabetes mellitus, experiment, blood, insulin resistance