关键词: 茯苓, 抗诱变, 微核, 镉

Abstract: To examine whether acanthopanasia and hoelen have mutagenic effects on the genetic damage of somatic cells and study the antagonism of two Chinese herbal medicines on mutagenesis induced by cadmium. Methods Seventy mice were randomly divided into five groups:negative control(N.S),cadmium sulfate mutagenesis groups（1/5 half lethal dose， 17.6 mg•kg^-1）,acanthopanasia groups（1,2,4 g•kg^-1）,hoelen group（2.5,5.0,10.0 g•kg^-1）,acanthopanasia antimutagenicity group（cadmium sulfate +each acanthopanasia group）and hoelen antimutagenicity group（cadmium sulfate+ each hoelen group）,five mice per group. Drugs were given by mouth. According to Heddle,the micronucleus test was performed. Results The micronucleus(MN) rates in acanthopanasia groups were less than that in negative control（P<0.05）; the MN rates in hoelen groups had no obvious differences compared with negative control. The MN rates in acanthopanasia antimutagenicity groups and hoelen antimutagenicity groups were reduced significantly compared with cadmium sulfate mutagenesis group（P<0.05 or P<0.01）,but there was no obvious difference of the MN rate between different doses individuals（P>0.05）. The was no obvious difference of the MN rate between acanthopanasia antimutagen icity group and hoelen antimutagenicity group（P>0.05）. Conclusion Both acanthopanasia and hoelen have no mutagenic toxicity founded on the genetic damage of somatic cells,and have significant antagonistic effects on the genetic damage induced by cadmium sulfate,and they are good antimutagents.

Key words: hoelen, antimutagenicity, micronucleus test, cadmium