关键词: 聚乙二醇干扰素α-2a；利巴韦林；慢性丙型肝炎

Abstract:

Abstract:Objective
To discuss the curative effect of PEG-interferon α-2a combined with ribavirin in treatment of chronic hepatitis C,and clarify the feasibility of combined therapy in treatment of chronic hepatitis C.Methods 86 cases of chronic hepatitis C patients were divided into treatment group (n=38) and  control group(n= 48).The patients in treatment group were treated with polyethylene glycol α-2a interferon 180 μg,subcutaneous injection once a week,combined with ribavirin 1 000 mg,once daily oral administration,a total of 2 weeks of treatment;the patients in control group were given α-1b interferon 500 000 U intramuscularly once a day,combined with ribavirin 1 000 mg,once daily oral administration,for 24 weeks.According to pre-treatment ALT values,all the patients were divided into low ALT group (more than normal but less than or equal to three times the upper limit of normal) and high ALT group (more than 3 times the upper limit of normal but less than or equal to 10 times the upper limit
 of normal),and the virology,biochemistry,genotyping  before treatment,12 and 24 weeks after treatment,24 weeks after withdrawl were detected and compared  between two groups,as well as ALT,HCV RNA quantitative level  and virological response.Results Virological and biochemical complete response results showed   the efficacies in the treatment group were significantly better than those in control group 24 weeks after treatment and 24 weeks after withdrawl(P<0.05);the virological complete response rate in high ALT group was higher than that in low ALT group(P<0.05);the ALT level had no significant impact on the virological complete response in treatment group,the RNA quantitative level of HCV had no significant impact  on the virological complete response in control group and treatment group(P>0.05).The study of the effect of genotype on the virology indicated that there was significant difference between 1a group and 2a group at the end of treatment (P<0.05),but there was no significant difference between the other groups(P>0.05).The adverse reactions found in two groups were similar,and there was no significant difference. Conclusion The long-acting combination of pegylated interferon and ribavirin  in treatment for chronic hepatitis C is a very effective,and it can significantly increase the efficacy than general interferon.

Key words: PEG-IFNα-2a;ribavirin;chronic hepatitis C