麝鼠香与麝香抗炎及镇痛作用的比较研究

doi:国家中药管理局科研基金资助课题

麝鼠香与麝香抗炎及镇痛作用的比较研究

陈心智，邱智东^*，张永和，张辉

长春中医学院新药研发中心，吉林长春130117

收稿日期:2005-02-21 修回日期:1900-01-01 出版日期:2005-05-28 发布日期:2005-05-28
通讯作者: 邱智东

Comparison of anti-inflammation and analgesia between muskrat and moschus

CHEN Xin-zhi,QIU Zhi-dong^*, ZHANG Yong-he,ZHANG Hui

Research Center for Medicine, Changchun College of Traditional Chinese Medicine,Changchun 130117,China

Received:2005-02-21 Revised:1900-01-01 Online:2005-05-28 Published:2005-05-28
Contact: QIU Zhi-dong

摘要/Abstract

摘要： 目的：研究麝鼠香与麝香的抗炎及镇痛作用。方法：利用扭体法，对比观察麝鼠香与麝香的镇痛作用;应用二甲苯致炎模型及醋酸所致小鼠腹腔毛细血管通透性增加模型对比观察麝鼠香与麝香的抗炎作用。结果：麝鼠香与麝香均能明显减少冰醋酸所致的小鼠扭体次数（P<0.05或P<0.01），显著抑制二甲苯引起的小鼠耳肿胀（P<0.05或P<0.01），同剂量给药，麝香组的作用明显强于麝鼠香组；麝鼠香与麝香对醋酸所致的小鼠腹腔毛细血管通透性增加性炎症反应有明显的抑制作用（P<0.05或P<0.01），相同剂量给药，二者的作用差异无显著性（P>0.05）。结论：麝鼠香有类麝香样抗炎及镇痛作用。

关键词: 麝香, 药理学, 抗炎, 镇痛

Abstract: Objective To study the effects of muskrat and moschus of anti-inflammation and annalgesia. Methods The effects of muskrat and moschus of anti-inflammation were observed by using torsive-body method. The effects of muskrat and moschus of analgesia were observed by mice inflammation models caused by dimethylbenzene and mice models with reinforce permeability of abdominal cavity capillary caused by acetic acid. Results Both muskrat and moschus could significantly reduce the times of torsive-body in mice caused by glacial acetic acid (P<0.05 or P<0.01). And they obviously inhibited ear swelling of mice caused by dimethylbenzene (P<0.05 or P<0.01). The effects of moschus were more obvious than muskrat when they were given with the same dosage. Muskrat and moschus had obvious inhibitory effects on mice inflammation of reinforce permeability of abdominal cavity capillary caused by acetic acid (P<0.05 or P<0.01).They had no difference of effects when they were given with the same dosage（P>0.05）. Conclusion Muskrat and moschus have the same effects of anti-inflammation and analgesia.

Key words: moschus, pharmacology, anti-inflammation, analgesion

中图分类号:

R-332

陈心智，邱智东，张永和，张辉. 麝鼠香与麝香抗炎及镇痛作用的比较研究[J]. J4, 2005, 31(3): 414-416.

CHEN Xin-zhi,QIU Zhi-dong, ZHANG Yong-he,ZHANG Hui. Comparison of anti-inflammation and analgesia between muskrat and moschus[J]. J4, 2005, 31(3): 414-416.

[1]	治丁铭, 隋殿军, 岂蕊, 苗永迪, 韩冬, 娄石磊, 邱悦, 孙聪. 基于网络药理学探讨葛根治疗高脂蛋白血症的潜在作用靶点[J]. 吉林大学学报(医学版), 2018, 44(04): 724-730.
[2]	王波, 沈倩倩, 张华, 冯智英. 羟考酮联合右美托咪定用于腹腔镜下结肠癌根治术术后镇痛效果评价[J]. 吉林大学学报(医学版), 2017, 43(06): 1231-1236.
[3]	刘婕婷, 夏鑫, 申希平, 王迎斌. 罗哌卡因联合地佐辛多模式镇痛在小儿唇裂修复术中的应用及其术后镇痛效果评价[J]. 吉林大学学报(医学版), 2016, 42(04): 807-812.
[4]	沈楠, 陈钱, 齐玲, 陈雪, 黄成然, 唐海如, 安英, 林峰, 王艳春. 萱草花总黄酮含药血清对肝癌HepG2细胞增殖和凋亡的影响[J]. 吉林大学学报(医学版), 2016, 42(04): 737-741.
[5]	付雯雯, 江一川, 张虹, 翟婧卉, 王帅君, 于晓风, 曲绍春, 睢大筼. 乌头注射液对不同阶段炎症动物模型的抗炎作用[J]. 吉林大学学报(医学版), 2015, 41(03): 568-572.
[6]	周雁，敦元莉，林惠华，王庚. 超声引导下经腹横筋膜平面阻滞在经腹子宫手术术中和术后的镇痛效果评价[J]. 吉林大学学报(医学版), 2013, 39(6): 1264-1269.
[7]	严进军,庞磊,董愫,冯艳华,麻海春. 帕瑞昔布钠用于肾移植术后患者的镇痛效果及其安全性评价[J]. 吉林大学学报(医学版), 2013, 39(1): 138-142.
[8]	王杨, 张岩, 孙竹平, 刘敏. 阿司匹林和塞来昔布对乳腺癌细胞MCF-7中COX-2及VEGF表达的影响[J]. J4, 2009, 35(3): 456-461.
[9]	李艳辉, 韩灵, 王丹, 麻海春. 氟比洛芬酯超前镇痛效果及其对开胸患者术后肺功能影响的评价[J]. J4, 2009, 35(3): 515-518.
[10]	赵小霞,台桂香,马吉春,周静,方芳,宋献美,柳忠辉. 强力天麻杜仲胶囊活性成分的提取及其对巨噬细胞的抑制作用[J]. J4, 2009, 35(1): 55-58.
[11]	邢沈阳，乔萍，温得中，朱玉琢. 益母草提取液对小鼠遗传物质损伤的保护作用及对淋巴细胞功能的增强作用[J]. J4, 2008, 34(5): 799-801.
[12]	李国华，仇金鹏，冯春生，麻海春. 术后硬膜外自控镇痛对老年高血压患者循环功能和肺功能的影响[J]. J4, 2008, 34(5): 887-889.
[13]	林天慕，李红，管清香，杨世杰，王恩思. 前列舒通片对鼠的抗炎及镇痛作用[J]. J4, 2008, 34(3): 453-457.
[14]	苗春生，石艳，于晓艳，李才. 胡芦巴对糖尿病大鼠肾脏基质金属蛋白酶-2活性的影响[J]. J4, 2008, 34(1): 87-89.
[15]	张岩，王杨，闫秀欣. 阿司匹林和塞来昔布对乳腺癌细胞MCF-7增殖的影响[J]. J4, 2007, 33(5): 901-904.