关键词: 病理学, 动脉, 病理学, 动脉重塑

Abstract: Objective To investigate the changes of arterial structure and function in patients with hypertension. Methods Structures and functions of aortic, carotid, brachial, radial, ophthalmic and retinal arteries were measured by Doppler ultrasound technique in 55 patients with mild to moderate hypertension. 24 normotensive subjects were served as control. Results The dimension (Ds), intima-media thickness (IMT) and IMT/D radial, resistance index (RI) and stiffness (S) were increased, while the peak velocity in systole (PVS) and maximal shear rate (SR), cross-sectional compliance (CSC) and distensibility in aortic, carotid and brachial arteries were decreased in hypertensive patients compared with controls (P<0.05 or P<0.01). IMT,IMT/D radial,and RI of radial artery were higher in hypertensive patients than those in control group (P<0.01 or P<0.05). The blood flow velocity of the end-diastolic phase of ophthalmic and central retinal artery were distinctly decreased，while RI was increased in hypertensive patients compared with controls(P<0.05 and P<0.01).There were no changes of PI in aortic, carotid, brachial, radial, ophthalmic and central retina arteries (P>0.05). Conclusion There are changes in arterial structure and function in mild-to-moderate essential hypertension, which are more significant in the vascular remodeling of large and moderate arteries.

Key words: pathology, arteries, pathology, arterial remodel