关键词: 受体, 雌激素, 受体, 孕酮, 原癌基因蛋白质c-bcl-2, 免疫组织化学

Abstract: Objective To determine the progesterone receptor (PR), estrogen receptor (ER), and Bcl-2 protein expressions in endometrial carcinoma and their clinical significances. Methods The expressions of PR, ER, and Bcl-2 in a total of 104 frozen tissues of endometrial carcinoma and 30 cases of paracarcinoma tissues were examined by immunohistochemistry. Results ①The expressions rates of PR, ER, and Bcal-2 protein in endometrial carcinoma were 65.38%, 46.15%, and 50.84%, respectively. They were 66.66%, 60.00%,and 26.66%, respectively, in parcarcinoma tissues. Statistically difference was found in the expressions of Bcl-2 between two groups (P<0.05), while it was not found in the expressions of ER and PR. ②Expression of PR was positively correlated with that of Bcl-2 (r=0.216，P<0.05). There was no relation between ER and Bcl-2. ③Positive expression rate of ER in 16 lymph node metastasis cases was 50.00%, those of PR and Bcl-2 were 12.50% and 25.00%,respectively. Positive expression rates of ER, PR, and Bcl-2 in 88 non lymph node metastasis cases were 45.45%, 75.00%,and 59.09%,respectively. Expressions of PR and Bcl-2 had statistically differences in the cases of lymph node metastasis or non-metastasis　(P<0.05), while ER had not.　④Expression of PR was higher in highly differentiated endometrial adenocarcinoma than that in poorly differentiated one. Conclusion Positive expression rate of Bcl-2 in endometrial carcinoma is high, it is positively correlated with PR expression. PR and Bcl-2 positive expression rates in lymph node metastases cases are low. PR and Bcl-2 might be available prognostic factors.

Key words: receptor, estrogen, receptor, progesterone, proto-oncogene proteins c-bcl-2, immunohistochemistry