关键词: 心肌梗塞, 药物疗法, 超氧化物歧化酶, 血液, 丙二醛, 血液, 活性氧

Abstract: Objective To observe the protective effects of Shengmai inject on on ischemic myocardium in patients with acute myocardial infarction (AMI). Methods Forty-eight AMI patients were randomly divided into Shengmai injection treatment group (n=26) and non-Shengmai injection treatment group (n=22), and 24 normal healthy subjects were used as controls. The levels of MDA and SOD in serum were assayed with colorimetric methods. Results The levels of SOD in all AMI patients were obviously lower than that in normal healthy sujects before therapy, and the levels of MDA were significantly increased (P<0.01); as the time went on, the level of SOD was increased gradually in Shengmai injection treatment group, and MDA level was decreased gradually. Although the levels of MDA and SOD in non-Shengmai injection treatment group had the same trends with the Shengmai injection treatment group, but there was marked difference of the serum content between the two groups (P<0.01). Conclusion With the effects of anti-oxygen-derived free radicals and anti-lipid peroxidation, Shengmai injection has protective effects on the ischemic myocardium in patients with AMI.

Key words: myocardial infarction, drug therapy, superoxide dismutase, blood, malondialdehyde, blood, active oxygen