关键词: 血液, T淋巴细胞亚群, 白细胞介素10, 血液, 白细胞介素12, 血液

Abstract: Objective To examine the changes of T lymphocyte subsets, IL-10 and IL-12 levels in patients with chronic hepatic diseases. Methods Serum IL-10, IL-12 and T lymphocyte subsets in 68 patients with various clinic types of viral hepatic diseases were detected by double-sandwich ELISA and erythrocyte garland test, respectively. Results CD4⁺，CD4⁺/CD8⁺ in patients with different clinic types of chronic hepatic disease were significantly decreased, and CD8⁺ cells were significantly increased compared with control, and IL-10, IL-12 levels in patients with chronic hepatitis B and hepatocirrhosis markedly increased. CD4⁺, CD4⁺/CD8⁺, and IL-12 in HBeAg positive hepatitis group were markedly lower than those in HBeAg negative hepatitis group. The number of CD8⁺ cells and IL-10 level were significantly higher than those in HBeAg negative hepatitis group. Conclusion The immunological function is disorder in patients with chronic HBV hepatic disease, and CD4⁺, CD4⁺/ CD8⁺, IL-10, and IL-12 levels are related to state of HBV replication carrier or the active degree of HBV in patients with chronic hepatic disease.

Key words: blood, T-lymphocyte subsets, interleukin-10, blood, interleukin-12, blood