18F-FDG PET/CT与MRI对乳腺癌诊断价值的比较

J4 ›› 2011, Vol. 37 ›› Issue (4): 746-749.

18F-FDG PET/CT与MRI对乳腺癌诊断价值的比较

赵继红¹|丁军²|徐松柏³|王显荣²|付卫光 ²

1. 吉林省肿瘤医院放射线科|吉林长春 130012；2. 吉林大学中日联谊医院放射线科| 吉林长春 130033；3. 吉林大学第一医院神经外科| 吉林长春 130021

收稿日期:2011-04-06 出版日期:2011-07-28 发布日期:2011-07-28
通讯作者: 丁军（Tel：0431-84997637,E-mail:dingjun@jlu.edu.cn) E-mail:dingjun@jlu.edu.cn
作者简介:赵继红（1966-）|女|吉林省长春市人|副教授|医学博士|主要从事乳腺癌MRI方面的研究。
基金资助:
吉林省科技厅科技发展计划项目资助课题（200905170）

Comparison of diagnosis value between 18F-FDG PET/CT and MRI in breast cancer

ZHAO Ji-hong¹,DING Jun²,XU Song-bai³|WANG Xian-rong2,FU Wei-guang²

1. Department of Radiology,Tumor Hospital,Jilin Province,Changchun 130012,China|2. Department of Radiology,China-Japan Union Hospital,Jilin University,Changchun 130033,China;3. Department of Neurosurgery,First Hospital,Jilin University,Changchun 130021,China

Received:2011-04-06 Online:2011-07-28 Published:2011-07-28

摘要/Abstract

摘要：

目的：比较18F-FDG PET/CT和MRI在乳腺癌诊断中的作用。方法：选择29例怀疑乳腺癌的患者作为研究对象，10 d内进行PET/CT、MRI检查及得到病理结果。以病理结果作为金标准，计算18F-FDG PET/CT和MRI诊断乳腺癌的灵敏度、特异度及准确度。结果：组织病理学证实在29例患者中，良性肿瘤9例，恶性肿瘤20例。MRI评价乳腺癌的灵敏度、特异度、准确率分别为85.0%、66.7%和79.3%，PET/CT灵敏度、特异度、准确率分别为90.0％、88.9％和89.6％，PET/CT诊断准确度要高于乳腺MRI，但两者之间差异无统计学意义（χ2=1.17，P>0.05）；PET/CT通过全身显像还显示了未预测到的左侧锁骨上淋巴结及骨转移3例。结论：在乳腺癌原发灶诊断准确性方面，PET/CT与MRI差异无统计学意义，但在揭示远处转移、准确分期以指导临床治疗方面，PET/CT要优于乳腺MRI。

关键词: 乳腺肿瘤；正电子发射型计算机断层显像；核磁共振成像

Abstract:

Abstract:Objective To compare the effects between 18F-fluorodeoxyglucose(18F-FDG)PET-CT and MRI in diagnosis of breast cancer．Methods 29 patients with suspicious masses in breast were selected,18F-FDG PET/CT and MRI scanning were performed and their pathological results were gotten within 10 d．The sensitivities,specificities and accuracies of PET/CT and MRI in detecting breast cancer were calculated by using surgery or biopsy results as diagnostic golden standard．Results 20 malignant and 9 benign breast lesions of the 29 patients were proven histologically after surgery or biopsy．The sensitivity，specificity and accuracy value obtained by MRI were 85.0％,66.7％ and 79.3％ respectively,and they were 90.0％,88.9％ and 89.6％ for PET/CT．The accuracy of PET/CT was a little higher than that of MRI,but there was no significant difference between them (χ2=1.17，P>0.05). PET/CT found 3 patients with left infraclavicular lymph node metastasis and bone metastasis. Conclusion There is no significant difference between PET/CT and MRI in detecting breast cancer. But PET/CT is superior to MRI in evaluating distant metastasis and accurate staging to guide therapy.

Key words: breast neoplasms；positron emission computed tomography；magnetic resonance imaging

中图分类号:

R737.9

赵继红|丁军|徐松柏|王显荣|付卫光 . 18F-FDG PET/CT与MRI对乳腺癌诊断价值的比较[J]. J4, 2011, 37(4): 746-749.

ZHAO Ji-hong,DING Jun,XU Song-bai|WANG Xian-rong,FU Wei-guang. Comparison of diagnosis value between 18F-FDG PET/CT and MRI in breast cancer[J]. J4, 2011, 37(4): 746-749.

[1]	王剑锋\|方芳\|刘扬\|吴嘉慧\|龚守良\|王志成. Egr1介导的人截短型凋亡诱导因子表达载体的构建及其在乳腺癌MCF-7细胞中的辐射诱导表达规律[J]. J4, 2012, 38(3): 521-527.
[2]	张伟红\|张西臣\|邢沈阳\|李泽中\|宫鹏涛\|李建华\|杨举\|倪劲松. DHRS7对人乳腺癌细胞MCF-7细胞周期的影响及其在乳腺癌组织中的表达[J]. J4, 2012, 38(3): 537-542.
[3]	王秀兰\|赵彤\|陈丹峰\|李蕾\|郭海燕\|迟宝荣. p18 mRNA的表达与食管癌的关系[J]. J4, 2011, 37(5): 919-922.
[4]	王杨, 刘敏, 王兆鹏. 乳腺癌患者血清中环氧化酶-2的表达及意义[J]. J4, 2010, 36(6): 1118-1121.
[5]	雒伟伟, 邢沈阳, 赵志辉, 张西臣. 转录因子FOXD1在乳腺癌组织中的表达及意义[J]. J4, 2010, 36(4): 703-707.
[6]	马海英, 赵瑾瑶, 金伟, 孔力. 川芎嗪对转基因多药耐药细胞K562/MDR耐药性的逆转作用[J]. J4, 2009, 35(4): 599-603.
[7]	王杨, 张岩, 孙竹平, 刘敏. 阿司匹林和塞来昔布对乳腺癌细胞MCF-7中COX-2及VEGF表达的影响[J]. J4, 2009, 35(3): 456-461.