关键词: 正视化, 眼球, 生长, 动物模型

Abstract: Abstract:Objective To study the emmetropization in guinea pig eyes during the normal development from birth in order to provide theoretical basis to use guinea pigs as model for research on near-sightedness. Methods Sixty-four guinea pigs were assigned to 8 groups (n=8,4 male/4 female).Each group underwent a series of ocular examinations at one of the 8 time-points (0,1,2,3,5,7,9 and 11 weeks), including refraction(R),radius of corneal curvature (RCC),depth of anterior segment(AS),thickness of crystalline lens (CL),length of vitreous chamber (VC)and axial length (AL).Pooled results from both eyes of the same animals with mixed sexes can be used for further assessment of the emmetropization with the associated biometrical changes of the eye.Correlations were made between RCC,AS,CL,VC,AL and R. Results There were no significant differences between the right eye and left eye or between male and female in results of all the examinations. The refraction at birth was (+5.25±0.22 )D　 in guinea pigs.This value rapidly decreased during the first 3 weeks,approaching(+1.34±0.61)　 D by 11 weeks. There was no significant difference in refraction between 9 and 11 weeks (Ｐ= 0.21 5). The RCC was (3.23±0.01) mm at birth,AS was (1.20±0.00) mm at birth,CL was (2.72±0.02) mm at birth and VC was (3.27±0.01) mm at birth,they increased within the first 3 weeks despite a transient decrease in the RCC within the first week.Such an increase continued except the AS which became constant after 3 weeks.The VC was more correlated to the emmetropization (r=－0.818，P<0.01) than the other 3 components (r=－0.558 to －0.680，P<0.01 ). Conclusion In guinea pigs,the end point of emmetropization is among 9 to 11 weeks,the emmetropization process in guinea pigs is mainly related to the increase in the vitreous chamber lenghth.

Key words: emmetropization, eye, growth, animal model