吉林大学学报(医学版) ›› 2018, Vol. 44 ›› Issue (05): 1073-1077.doi: 10.13481/j.1671-587x.20180535

• 影像学 • 上一篇    下一篇

乳腺癌患者超声图像特征与人类上皮生长因子受体2和Ki-67阳性表达的关联性分析

郑芳1, 欧阳征仁1, 欧阳靖霖1, 周诗力1, 罗文2   

  1. 1. 南华大学附属第二医院超声科, 湖南 衡阳 421001;
    2. 湖南环境生物职业技术学院内科学教研室, 湖南 衡阳 421001
  • 收稿日期:2018-01-23 出版日期:2018-09-28 发布日期:2018-11-20
  • 通讯作者: 罗文,讲师(Tel:0734-8591999,E-mail:luowen8257@yahoo.com.cn) E-mail:luowen8257@yahoo.com.cn
  • 作者简介:郑芳(1983-),女,湖南省衡阳市人,主治医师,医学硕士,主要从事超声医学方面的研究。
  • 基金资助:
    湖南省教育厅科研基金资助课题(16C0557)

Analysis on correlations between ultrasound features and positive expressions of CerbB-2and Ki-67 in patients with breast cancer

ZHENG Fang1, OUYANG Zhengren1, OUYANG Jinglin1, ZHOU Shili1, LUO Wen2   

  1. 1. Department of Ultrasonography, Second Affiliated Hospital, University of South China, Hengyang 421001, China;
    2. Department of Internal Medicine, Hunan Vocational College of Environmental Biology, Hengyang 421001, China
  • Received:2018-01-23 Online:2018-09-28 Published:2018-11-20

摘要: 目的:探讨乳腺癌患者超声图像特征与其分子生物学指标——人类上皮生长因子受体2(CerbB-2)和Ki-67表达的关系。方法:收集107例经病理证实为乳腺癌患者的超声声像图表现及石蜡切片资料,分析超声声像图特征与CerbB-2和Ki-67的关系。结果:乳腺癌组织中,CerB-2阳性表达率为73.83%(79/107),Ki-67阳性表达率为81.21%(87/107),两者表达呈正相关关系(r=0.264,P=0.001)。乳腺癌边界、直径、形状、肿瘤纵横比>1、内部回声不均匀、后方回声衰减、肿块内微小钙化和血流分级2~3级与乳腺癌CerB-2表达有关联(P<0.05)。肿瘤纵横比>1、内部回声不均匀、后方回声衰减、肿块内微小钙化和血流分级2~3级与乳腺癌Ki-67表达有关联(P<0.05)。多因素Cox回归分析,乳腺癌患者预后独立影响因素包括CerB-2蛋白(⧻)表达(P=0.002)、Ki-67蛋白(⧻)表达(P=0.006)、血流分级2~3级(P=0.036)、后方回声衰减(P=0.001)和肿瘤纵横比>1(P=0.002)。结论:乳腺癌超声图像的某些表现与乳腺癌组织中CerbB-2和Ki-67阳性表达有关联。

关键词: 乳腺肿瘤, 人类上皮生长因子受体2, Ki-67蛋白, 蛋白超声诊断

Abstract: Objective:To explore the correlations between the ultrasound features and the expressions of the molecular biological indicator human epidermal growth factor receptor 2(CerbB-2) and Ki-67 in the patients with breast cancer. Methods:The ultrasonographic characteristics and paraffin section materials of 107 patients with breast cancer confirmed by pathology were collected. The correlations between the ultrasonographic characteristics and the expressions of CerbB-2 and Ki-67 were analyzed. Results:The positive expression rates of CerbB-2 and Ki-67 in breast cancer tissue were 73.83%(79/107) and 81.21%(87/107), respectively;the expressions of CerbB-2 and Ki-67 were positively correlated(r=0.264,P=0.001).There were obvious correlations between the edge, size, shape, orientation, hyper-echoic halo, rear echo attenuation,micro calcification, flow signal 2-3 grade of breast cancer and the expression of CerbB-2 (P<0.05).There were obvious correlations between the aspect ratio >1, hyper-echoic halo, rear echo attenuation,micro calcification, flow signal 2-3 grade of breast cancer and the expression of Ki-67 (P<0.05). The results of multivariate Cox regression analysis showed that CerbB-2 (⧻)(P=0.002), Ki-67 (⧻)(P=0.006), blood flow 2-3 grade (P=0.036), rear echo attenation (P=0.001),and aspect ratio>1 (P=0.002) were the independent prognostic factors of breast cancer. Conclusion:There are significant correlations between some ultrasound features of breast cancer and the positive expressions of CerbB-2 and Ki-67 in the breast cancer tissue.

Key words: breast neoplasms, human epidermal growth factor receptor 2, Ki-67 protein, ultrasound diagnosis

中图分类号: 

  • R737.9