胡氏骨痛颗粒抗炎作用的药理学研究

doi:国家重点科技攻关项目

胡氏骨痛颗粒抗炎作用的药理学研究

李兴志¹，李贺¹，于晓风²，曲绍春²，睢大员^2*

1.吉林大学第一医院康复疼痛诊疗中心，吉林长春130021；2.吉林大学药学院药理学教研室，吉林长春130021

收稿日期:2004-03-05 修回日期:1900-01-01 出版日期:2005-01-28 发布日期:2005-01-28
通讯作者: 睢大员

Pharmacological research on anti-inflammatoryeffects of Hushigutong Granule

LI Xing-zhi¹, LI He¹, YU Xiao-feng², QU Shao-chun², SUI Da-yuan^2*

1. Center of Diagnosis and Treatment for Rehabilitation and Ache, First Hospital, Jilin University,Changchun 130021, China;2.Department of Pharmacology,College of Pharmacy, Jilin University，Changchun 130021,China

Received:2004-03-05 Revised:1900-01-01 Online:2005-01-28 Published:2005-01-28
Contact: SUI Da-yuan

摘要/Abstract

摘要： 目的:观察胡氏骨痛颗粒（HGG）的抗炎作用。方法：Wistar大鼠随机分为对照组(羧甲基纤维素钠)、阳性药组(阿斯匹林200 mg•kg^-1)及HGG 15、30和60 g•kg^-1剂量组，每组10只。通过小鼠二甲苯性耳肿胀，大鼠蛋清性、脚叉菜胶性足跖肿，巴豆油气囊肿和毛细血管通透性实验观察HGG的抗炎作用。结果：HGG 30和60 g•kg^-1对小鼠二甲苯性耳肿胀、大鼠蛋清和脚叉菜胶性足跖肿、巴豆油气囊肿及组胺所致毛细血管通透性的增加均有明显抑制作用，与对照组比较差异有显著性（P<0.05或P<0.01）。结论：HGG对多种炎症模型均具有明显的对抗作用。

关键词: 药物疗法, 胡氏骨痛颗粒, 抗炎作用, 药理研究

Abstract: Objective To investigate the anti-inflammatory effects of Hushigutong Granule. Methods Fifty Wistar rats were randomly divided into control group,aspirin group, and three groups of Hushigutong Granule at different doses (15,30,and 60 mg•kg^-1). Anti-inflammatory effects of Hushigutong Granule were carried through inflammatory models of auris swell induced by dimethylbenzene in mice, of foot swell induced by egg white and carageen glue in rats, of gasbag swell induced by croton oil in rats and penetration of capillary vessel. Results Hushigutong Granule (30 and 60 mg•kg^-1) had significant inhibitory action on auris swell induced by dimethylbenzene in mice, foot swell induced by egg white and carageen glue, gasbag swell induced by croton oil and penetration of capillary vessel in rats. There were significant differences compared with control group (P<0.05 or P<0.01). Conclusion Hushigutong Granule has significant inhibitory effects on many experimental inflammatory models.

Key words: drug therapy, Hushigutong Granule, antiinflammatory effect, pharmacological research

中图分类号:

R285

李兴志，李贺，于晓风，曲绍春，睢大员. 胡氏骨痛颗粒抗炎作用的药理学研究[J]. J4, 2005, 31(1): 71-73.

LI Xing-zhi, LI He, YU Xiao-feng, QU Shao-chun, SUI Da-yuan. Pharmacological research on anti-inflammatoryeffects of Hushigutong Granule[J]. J4, 2005, 31(1): 71-73.

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