纳米载体逃逸溶酶体机制及其调控的研究进展

doi:10.13481/j.1671-587x.20170435

吉林大学学报(医学版) ›› 2017, Vol. 43 ›› Issue (04): 845-848.doi: 10.13481/j.1671-587x.20170435

纳米载体逃逸溶酶体机制及其调控的研究进展

孙茂蕾¹, 徐晓薇², 顾中一², 刘杰¹, 高雪彬¹, 孟许亚¹, 孙宏晨¹

1. 吉林大学口腔医院病理科, 吉林长春 130021;
2. 吉林大学口腔医院牙周病科, 吉林长春 130021

收稿日期:2016-11-08 出版日期:2017-07-28 发布日期:2017-08-01
通讯作者: 孙宏晨,教授,主任医师,博士研究生导师(Tel:0431-88796010,E-mail:hcsun@mail.jlu.edu.cn) E-mail:hcsun@mail.jlu.edu.cn
作者简介:孙茂蕾(1992-),女,吉林省德惠市人,在读医学硕士,主要从事颌骨重塑机制和纳米材料与转基因治疗方面的研究。
基金资助:
国家自然科学基金资助课题（81320108011，81271111，81600879）

Research progress in mechanisms of lysosome escaped by nanocarriers and its regulation

Received:2016-11-08 Online:2017-07-28 Published:2017-08-01

摘要/Abstract

摘要： 纳米载体传递药物或核酸进入细胞，要穿透细胞膜，逃逸溶酶体并进入细胞核，其中逃逸溶酶体是纳米载体发挥作用的关键步骤。近年来，国内外许多学者根据纳米载体逃逸溶酶体的机制，利用大分子对现有纳米载体进行修饰或合成新型纳米载体。本文作者就纳米载体进入细胞的屏障、逃逸溶酶体机制及根据逃逸机制对其进行修饰调控3个方面做进行分析和综述。

关键词: 修饰调控, 纳米载体, 细胞屏障, 逃逸溶酶体

中图分类号:

R318.08

孙茂蕾, 徐晓薇, 顾中一, 刘杰, 高雪彬, 孟许亚, 孙宏晨. 纳米载体逃逸溶酶体机制及其调控的研究进展[J]. 吉林大学学报(医学版), 2017, 43(04): 845-848.

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纳米载体逃逸溶酶体机制及其调控的研究进展

Research progress in mechanisms of lysosome escaped by nanocarriers and its regulation

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