OSAHS并发2型糖尿病患者血浆ET-1和血清NO测定及其与血糖和睡眠呼吸暂停指数的相关性分析

J4 ›› 2010, Vol. 36 ›› Issue (6): 1126-1129.

OSAHS并发2型糖尿病患者血浆ET-1和血清NO测定及其与血糖和睡眠呼吸暂停指数的相关性分析

叶辉¹|修世国²|刘艳丽²

1.福建省厦门市第二医院耳鼻咽喉科| |福建厦门 361021；2.延边大学附属医院耳鼻咽喉科|吉林延吉 133000

收稿日期:2010-03-01 出版日期:2010-11-28 发布日期:2010-11-28
通讯作者: 修世国(Tel:0433-2660300,E-mail: entyh@126.com) E-mail:entyh@126.com
作者简介:叶辉（1972-）|男|黑龙江省拜泉县人|主治医师|医学硕士|主要从事睡眠呼吸障碍疾病的临床研究。
基金资助:
吉林省教育厅“十一五”科学技术研究项目资助课题（吉教科合字［2008］第17号）

Determination of |levels of plasma ET-1 and serum NO in patients with OSAHS complicated with type |2 diabetes and correlation analysis on fasting blood sugar and AHI

YE Hui¹,XIU Shi-guo²,LIU Yan-li²

1. |Department of Otorhinolaryngology,Second Hospital of Xiamen,Xiamen 361021,China;2. Department of Otorhinolaryngology,Affiliated Hospital| Yanbian University,Yanji 133000,China

Received:2010-03-01 Online:2010-11-28 Published:2010-11-28

摘要/Abstract

摘要：

目的：探讨检测阻塞性睡眠呼吸暂停低通气综合征(OSAHS)并发2型糖尿病患者血清一氧化氮(NO)、血浆内皮素1(ET-1)与管内皮细胞功能失调的相关性，为临床进行血管内皮保护提供理论根据。方法： OSAHS患者42例，2型糖尿病患者38例，OSAHS并发2型糖尿病患者32例，经多导睡眠监测系统(polysomnography,PSG)及空腹血糖检测确诊。所有入选者在睡眠监测结束，晨醒10 min内采取肘静脉血，检测血浆ET-1及血清NO。结果：OSAHS并发2型糖尿病组与OSAHS组和糖尿病组患者比较，血浆ET-1浓度升高(P<0.05)，血清NO 浓度及NO/ET-1比值降低(P<0.05)。直线相关分析显示，糖尿病组患者血浆ET-1水平与血糖呈正相关(r=0.729，P<0.05)，血清NO水平与血糖呈负相关(r=－0.586,P<0.05)；OSAHS组患者血浆ET-1水平与睡眠呼吸暂停指数(AHI)呈正相关(r=0.820,P<0.05)，血清NO水平与AHI呈负相关(r=－0.734,P<0.05)。结论：OSAHS并发2型糖尿病患者与OSAHS患者和糖尿病患者比较，血浆ET-1浓度升高，血清NO 浓度、NO/ET-1比值降低，说明OSAHS并发2型糖尿病患者血管内皮受损程度更加严重。

关键词: 睡眠呼吸暂停低通气综合征, 阻塞性；内皮素1；一氧化氮；糖尿病；多导睡眠监测

Abstract:

Abstract:Objective To study the relationship between the unbalance of internal environment of blood vessel and obstructive sleep apnea-hypopnea syndrome(OSAHS) compliated with type 2 diabetes and provide a theoretical basis for protection of the blood vessel endodermis.Methods 42 patients with OSAHS,38 patients with type 2 diabetes and 32 patients with OSAHS complicated with type 2 diabetes were selected,all the patients were diagnosed by polysomnography(PSG) and the level of fasting blood sugar.The plasma endothelin(ET-1)and serum nitric oxide(NO) levels were measured by radioimmunoassay and nitrate reductase method respectively.Results The level of plasma ET-1 in patients with OSAHS complicated with type 2 diabetes was higher,the serum NO level and NO/ET-1 were lower than those in the patients with OSAHS and type 2 diabetes,there were significant differences (P<0.05).The linear correlation results showed that the plasma ET-1 level was positively correlated with the fasting blood sugar(r=0.729),the serum NO level was negatively correlated with fasting blood sugar(r=－0.586) in the patients with type 2 diabetes. The plasma ET-1 level was positively correlated with AHI(r=0.820),the serum NO level was negatively correlated with AHI(r=－0.734) in OSAHS patients.Conclusion The plasma ET-1 level of patients with OSAHS complicated with type 2 diabetes is higher,the serum NO level and NO/ET-1 are lower than those in the patients with OSAHS and type 2 diabetes.It demonstrates that the injury of the blood vessel endodermis is more serious in patients with OSAHS complicated with type 2 diabetes.

Key words: obstructive sleep apnea-hypopnea syndrome; , endothelin-1;nitric oxide;diabetes mellitus;polysomnography

中图分类号:

叶辉|修世国|刘艳丽. OSAHS并发2型糖尿病患者血浆ET-1和血清NO测定及其与血糖和睡眠呼吸暂停指数的相关性分析[J]. J4, 2010, 36(6): 1126-1129.

YE Hui,XIU Shi-guo,LIU Yan-li. Determination of |levels of plasma ET-1 and serum NO in patients with OSAHS complicated with type |2 diabetes and correlation analysis on fasting blood sugar and AHI[J]. J4, 2010, 36(6): 1126-1129.

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