强直性脊柱炎并发干燥综合征患者的临床特点及其实验室检查结果分析

J4 ›› 2012, Vol. 38 ›› Issue (6): 1183-1186.

强直性脊柱炎并发干燥综合征患者的临床特点及其实验室检查结果分析

常利华¹|蒋莉¹|郭韵¹|张晓莉¹|李忠义²|王晓非¹

1.中国医科大学附属盛京医院风湿免疫科|辽宁 |沈阳 110022；2.沈阳医学院奉天医院手外二科|辽宁 |沈阳 |110024

收稿日期:2012-05-24 发布日期:2012-11-28
通讯作者: 王晓非（Tel:024-96615-1-27111,E-mail:vincentclh@126.com） E-mail:vincentclh@126.com
作者简介:常利华（1982-）|男|辽宁省阜新市人|医师|医学硕士|主要从事风湿病的临床研究。
基金资助:
辽宁省科技厅科学计划项目资助课题（2011225015);辽宁省医学高峰建设工程重点科研项目资助课题（200931）

Analysis of |clinical features and laboratory fingdings in |patients with ankylosing spondylitis complicatedwith |Sjogren’

CHANG Li-hua¹,JIANG Li¹,GUO Yun¹,ZHANG Xiao-li¹,LI Zhong-yi²,WANG Xiao-fei¹

1.Department of Rheumatology,Affiliated Shengjing Hospital,China Medical University,Shenyang 110022,China|2. Department of |Hand Surgery,Fengtian Hospital,Shenyang Medical College,Shenyang 110024,China

Received:2012-05-24 Published:2012-11-28

摘要/Abstract

摘要：

目的：阐明强直性脊柱炎（AS）并发干燥综合征(SS)患者的特点，为该病的治疗及并发症的防治提供依据。方法：选择确诊的AS并发SS患者11例，总结临床特点和实验室检查结果，分别比较AS并发SS与单纯AS和单纯SS患者外周关节受累率、人类白细胞抗原-B27(HLA-B27)阳性率、抗核抗体(ANA)阳性率和C反应蛋白(CRP)、血沉(ESR)及免疫球蛋白水平。结果：11例患者均符合AS和SS的诊断标准，均有腰背痛与口干和(或)眼干症状；外周关节受累9例，葡萄膜炎1例；影像学示骶髂关节炎双侧≥2级9例，单侧3级1例，单侧4级1例；HLA-B27阳性7例，HLA-B27阳性率(63.6%)明显低于单纯AS患者(92.9%)(P<0.05)；唾液腺放射性核素检查阳性9例；泪液分泌试验阳性11例；ANA阳性9例，ANA阳性率(81.8%)与单纯SS患者(84.8%)比较差异无统计学意义；抗SSA抗体阳性8例；抗SSB抗体阳性6例；唇腺病理检查阳性11例。AS并发SS患者CRP、ESR和免疫球蛋白水平高于单纯AS和SS患者，但差异无统计学意义(P>0.05)；与AS患者比较，AS并发SS患者高球蛋白血症发生率升高(P<0.05)。结论：AS和SS可以同时发生，两病同时并发患者更易出现外周关节受累。

关键词: 强直性脊柱炎；干燥综合征, 抗核抗体, 免疫球蛋白

Abstract:

Abstract:Objective To clarify the characteristics of the patients with ankylosing
spondylitis (AS) complicated with Sjogren’[KG-*3]s syndrome (SS),and to provide basis for its treatment and prevention of complications.Methods 11 cases diagnosed as AS complicated with SS were selected,and the clinical features and laboratory fingdings were summarized retrospectively;the rate of involved joints,HLA-B27 positive rate,antinuclear antibody(ANA)positive rate,and the levels of C-eaction protein(CRP),erythrocyte sedimentation rate (ESR) and immunoglobulin were compared between the patients with AS complicated with SS and the simple AS or SS patients.Results All the  11 patients were in line with the diagnostic criteria for AS and SS with low back pain and siccaymptoms;peripheral joints were involved in 9 cases.1 case had uveitis;the imaging studies showed that there were 9 cases of grade 2 bilateral sacroiliitis and above,and 1 case of grade 3 unilateral sacroiliitis,1 case of grade 4 unilateral sacroiliitis.The HLA-B27 was positive in 7 cases,and the positive rate (63.6%) was ignificantly lower than thatof simple AS patients(92.9%)(P<0.05). The salivary radionuclide examination was positive in 9 cases;the Schirmer test was positive in 11 cases.Among 11 patients with AS complicated with SS,9 cases were ANA positive,the ANA positive rates had no significant difference between patients with AS complicated with SS(81.8%) and simple SS patients(84.89%).The anti-SSA ntibodies were positive in 8 cases;the anti-SSB antibodies were positive in 6 cases;the minor salivary gland biopsy was positive in 11 cases.The levels of CRP,ESR,and immunoglobulin of the patients with AS complicated with SS were higher than those of AS patients or SS patients,but the differences were not significant(P>0.05).Compared with AS patients,the incidence of hyperglobulinemia in patients with AS complicated with SS was increased(P<0.05).Conclusion AS and SS can occur at the same ime,and the patients with AS complicated with SS are prefer to peripheral joint involvement.

Key words: ankylosing spondylitis, Sjogren’syndrome, antinuclear antibody, immunoglobulin

中图分类号:

常利华|蒋莉|郭韵|张晓莉|李忠义|王晓非. 强直性脊柱炎并发干燥综合征患者的临床特点及其实验室检查结果分析[J]. J4, 2012, 38(6): 1183-1186.

CHANG Li-hua,JIANG Li,GUO Yun,ZHANG Xiao-li,LI Zhong-yi,WANG Xiao-fei. Analysis of |clinical features and laboratory fingdings in |patients with ankylosing spondylitis complicatedwith |Sjogren’[J]. J4, 2012, 38(6): 1183-1186.

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