吉林大学学报(医学版) ›› 2015, Vol. 41 ›› Issue (03): 648-651.doi: 10.13481/j.1671-587x.20150340

• 临床医学 • 上一篇    下一篇

不孕症患者促排卵治疗对子宫内膜息肉发生的影响

李悦1, 赵慧2, 黄冰玉1, 蔺军敏1, 徐影1, 崔满华1, 路英丽1   

  1. 1. 吉林大学第二医院妇产科, 吉林 长春 130041;
    2. 吉林大学基础医学院组织学与胚胎学系, 吉林 长春 130021
  • 收稿日期:2014-11-25 发布日期:2015-08-01
  • 通讯作者: 路英丽,副教授,副主任医师,硕士研究生导师(Tel:0431-88796331,E-mail:luyl@jlu.edu.cn);崔满华,教授,主任医师,博士研究生导师(Tel:0431-88796212;E-mail:cuimanhua@126.com) E-mail:luyl@jlu.edu.cn;cuimanhua@126.com
  • 作者简介:李悦(1988-),女,吉林省通化市人,在读医学硕士,主要从事生殖医学方面的研究。
  • 基金资助:

    吉林省科技厅科技发展计划项目资助课题(20130413026GH)

Effect of ovulation induction treatment on endometrial polyps formation in patients with infertility

LI Yue1, ZHAO Hui2, HUANG Bingyu1, LIN Junmin1, XU Ying1, CUI Manhua1, LU Yingli1   

  1. 1. Department of Obstetrics and Gynecology, Second Hospital, Jilin University, Changchun 130041, China;
    2. Department of Histology and Embryology, School of Basic Medical Sciences, Jilin University, Changchun 130021, China
  • Received:2014-11-25 Published:2015-08-01

摘要:

目的:探讨不孕症患者促排卵治疗与子宫内膜息肉发生的关系,阐明促排卵治疗中影响子宫内膜息肉发生的因素。方法:收集于门诊行宫腔镜检查的 76例做过促排卵治疗的不孕患者,分析不孕类型、不孕年限、促排卵治疗周期数和促排卵治疗中是否应用过促性腺激素释放激素类似物(GnRHa)与子宫内膜息肉发生的关系。结果:在促排卵治疗的不孕患者中,不同不孕类型患者间子宫内膜息肉发生率比较差异无统计学意义(χ2=0.071,P=0.790);不同不孕年限患者间子宫内膜息肉发生率比较差异无统计学意义(χ2=1.561,P=0.458);而不同促排卵治疗周期数患者间子宫内膜息肉发生率比较差异有统计学意义(χ2=4.992,P=0.025);促排卵治疗中是否应用过GnRHa患者间子宫内膜息肉发生率比较差异有统计学意义(χ2=18.899,P=0.000)。在经过促排卵治疗的患者中,随着促排治疗周期数的增加,不孕患者子宫内膜息肉的发生率增加,经过3个以上促排卵治疗周期的不孕患者子宫内膜息肉发生率高于经过1~2个促排卵治疗周期者(52.4% vs 25.5%,P=0.025)。在促排卵治疗中应用过GnRHa的不孕患者子宫内膜息肉发生率明显低于未应用过GnRHa的患者(16.0% vs 65.4%,P=0.000)。结论:促排卵治疗周期数的增加是不孕患者子宫内膜息肉发病的相关危险因素,而GnRHa可抑制不孕患者子宫内膜息肉的发生。

关键词: 促排卵, 促性腺激素释放激素类似物, 不孕症, 子宫内膜息肉

Abstract:

Objective To study the relationship between ovulation induction treatment and endometrial polyps formation in the patients with infertility, and to clarify the factors which influence the formation of endometrial polyps during ovulation induction treatment. Methods The data was collected from 76 infertile patients who had received ovulation induction treatment and came to outpatient service for hysteroscopy.The statistical analysis of the relationship between ovulation induction and endometrial polyps formation was performed in terms of infertility types, infertility duration, ovulation induction cycles and presence of gonadotrophin releasing hormone analogue(GnRHa) in the treatment. Results The occurence rates of endometrial polyps between the patients with different infertility types (χ2=0.071, P=0.790) or the different durations of intertility (χ2=1.561, P=0.458)had no significant differences while the occurrence rates between the patients with different ovulation cycles (χ2=4.992, P=0.025) or whether to use GnRHa (χ2=18.899, P=0.000) had significant differences.The occurrence rate of endometrial polyps was increased as the cycles of ovulation induction was increased.The occurrence rate of endometrial polyps was twice higher in the patients with three or more cycles of ovulation induction than that in the patients with one or two cycles (52.4% vs 25.5%, P=0.025).Meanwhile, the occurrence rate in the patients treated with GnRHa was significantly lower than that in the patients treated without GnRHa (16.0% vs 65.4%, P=0.000). Conclusion The increase of cycles of ovulation induction is a risk factor for endometrial polyps while the presence of GnRHa in the treatment is a protective factor against the formation of endometrial polyps.

Key words: ovulation induction, gonadotrophin releasing hormone analogue, infertility, endometrial polyps

中图分类号: 

  • R711.6