关键词: 再灌注, 抗原, CD95, 原癌基因蛋白质c-Bcl-2, 金纳多, 二裂银杏

Abstract: Objective To explore the protective effects of Ginaton on cerebral ischemia reperfusion injury and its influence on the exprssions of Fas and Bcl-2 protein in rats. Methods The global cerebral ischemia reperfusion model was established to investigate the expressions of Fas and Bcl-2 protein and the changes after given Ginaton were observed with immunochemistry technique. Results The expression of Fas protein appeared in simple ischemic group and reperfusion-3-hours group, and peaked 6 hours after reperfusion ,and decreased 24 hours after reperfusion. The expression of Bcl-2 peaked 3 hours after reperfusion, and gradually decreased 6 hours after reperfusion, and its expression reduced obviously 24 hours after reperfusion.In Ginaton group, the expression of Fas protein obviously decreased and Bcl-2 protein increased at corresponding time. Conclusion Ginaton can reduce the apoptosis following cerebral ischemia reperfusion and has protective effect on the injury of ischemia and reperfusion.

Key words: reperfusion, antigens, CD95, proto-oncogene proteins c-bcl-2, Ginaton, ginkgo bilobaon