横纹肌肉瘤的诊断及治疗研究进展

doi:10.13481/j.1671-587x.20170538

摘要/Abstract

摘要： 横纹肌肉瘤（RMS）是儿童常见的软组织肿瘤。染色体异常和分子通路的改变是其产生的主要原因。由于缺乏特异性临床表现，导致诊断较困难，传统的诊断方法仍以病理诊断为主，但无法观察疗效，判断预后，检测肿瘤的复发和转移。肿瘤标志物的不断出现很好地弥补了这一缺陷。尽管对发病机制进行了深入研究，但仍无法控制疾病的进展，这就需要研究者提出更为有效的治疗方法去解决这一难题。既往治疗都是以手术、化疗和放疗相结合为主，尽管综合治疗的方法已明显提高患者的治疗效果，但是对于中高危险度的患者疗效仍不理想。分子靶向治疗和免疫治疗方法的出现，为RMS的治疗提供了新的方向。本文作者就近几年来关于RMS的诊断、分子靶向和免疫治疗进行综述。

关键词: 横纹肌肉瘤, 分析靶向治疗, 染色体异常, 免疫治疗, 肿瘤标志物

中图分类号:

R738.7

原颖丽, 撒焕兰, 马克威. 横纹肌肉瘤的诊断及治疗研究进展[J]. 吉林大学学报(医学版), 2017, 43(05): 1059-1063.

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