吉林大学学报(医学版)

• 基础研究 • 上一篇    下一篇

原发性肝细胞癌患者Galectin-3和Galectin-9的表达及其与预后的关系

孔菲1, 马洪喜2,姜 晶1,宋莹1, 郭长松1,金美善2,牛俊奇3   

  1. 1.吉林大学第一医院临床流行病学研究中心,吉林 长春 130021;2.吉林大学第一医院病理诊断中心,吉林 长春 130021;3.吉林大学第一医院肝胆胰内科,吉林 长春 130021
  • 收稿日期:2013-10-19 出版日期:2014-03-28 发布日期:2014-05-28
  • 通讯作者: 金美善(Tel:0431-81875906,E-mail:jimsh88@hotmail.com); 牛俊奇(Tel:0431-81875101,E-mail:junqiniu@aliyun.com) E-mail:jimsh88@hotmail.com;junqiniu@aliyun.com
  • 作者简介:孔 菲(1986-),女,吉林省吉林市人,在读医学硕士,主要从事病毒性肝炎的临床研究。
  • 基金资助:

    国家自然科学基金资助课题(81001312,81072347,81202377);吉林省科技厅科研项目资助课题(201215035)

Expressions of Galectin-3 and Galectin-9 in hepatocellular carcinoma patients and their relationship with prognosis

KONG Fei1,MA Hong-xi2,JIANG Jing1,SONG Ying1,GUO Chang-song1, JIN Mei-shan2,NIU Jun-qi3   

  1. 1.Department of Clinical Epidemiology,First Hospital,Jilin University,Changchun 130021,China;2.Department of Pathological Diagnosis,First Hospital,Jilin University,Changchun 130021,China;3.Department of Hepatic-Billary-Pancreatic Medicine,First Hospital,Jilin University,Changchun 130021,China)
  • Received:2013-10-19 Online:2014-03-28 Published:2014-05-28

摘要:

目的: 探讨原发性肝细胞癌(HCC)患者肿瘤组织及其瘤旁组织中半乳糖凝集素3(Galectin-3)和半乳糖凝集素9(Galectin-9)的表达及其与预后的关系,阐明Galectin-3和Galectin-9在HCC发生发展过程中的意义。方法: 采用免疫组织化学法检测197例HCC患者肿瘤组织和131例瘤旁肝组织中Galectin-3和Galectin-9的表达水平;分析2种蛋白的表达与患者临床病理特征和预后的关系。结果:Galectin-9表达阳性率在HCC肿瘤组织和瘤旁组织中差异无统计学意义(P>0.05),高分化肿瘤组织中Galectin-9表达水平明显高于低分化肿瘤组织(P<0.05),脉管浸润者Galectin-9表达水平低于无脉管浸润者(P<0.05);Galectin-9高表达患者术后生存时间显著长于低表达和阴性表达患者(P<0.05)。肿瘤组织中Galectin-3表达阳性率显著高于瘤旁组织(P<0.01),但其表达水平与患者各临床病理特征及术后长期生存无关联。调整影响因素后多因素分析,仅丙肝感染(RR=2.86,95%CI:1.13~7.30,P=0.027)、多发肿瘤(RR=2.38,95%CI:1.39~4.07,P=0.002)、肿瘤直径>5 cm(RR=2.13,95%CI:1.21~3.76,P=0.009)和脉管浸润(RR=1.96,95%CI:1.07~3.62,P=0.030)成为影响HCC患者术后长期生存的独立影响因素。结论:Galectin-9表达水平与HCC患者肿瘤组织分化程度和脉管浸润有关联,但Galectin-9和Galectin-3表达水平与HCC患者的预后无关联。

关键词:  , 肝细胞肿瘤, 半乳糖凝集素3, 半乳糖凝集素9, 预后

Abstract:

Objective To investigate the  expressions of Galectin-3 and Galectin-9 in  the tumor tissue and adjacent cancer tissue of the patients with hepatocellular carcinoma (HCC) and their relationship with prognosis,and to explore the significance of Galectin-3 and Galectin-9 in the occurrence and development of HCC.Methods The expressions of Galectin-3 and Galectin-9 in 197 cases of HCC tissue  and 131 cases of adjacent cancer  tissue were detected by immunohistochemical technique;the association between the  expressions of Galectin-3 and Galectin-9 and  the  clinicopathologic characteristics  and prognosis of HCC patients were analyzed.Results There was no significant difference of the positive expression rate of Galectin-9 between HCC tumor tissue and adjacent cancer tissue (P>0.05).The expression levels of Galectin-9 in the  patients with  poorly differentiated HCC  or  with lymph-vascular invasion were lower than those in the  patients with well differentiated HCC  or  without lymph-vascular invasion (P<0.05);the patients with a high-level expression of Galection-9 showed a longer survival period compared with those with negative and low-level expression of Galectin-9 (P<0.05).The positive expression rate of Galectin-3 in HCC tumor tissue was significant higher than that in adjacent cancer tissue (P<0.01).The expression level of Galectin-3 in HCC tissue was not related to the clinicopathologic characteristics  and prognosis of the patients.After adjusting the influencing factors,the multivariate analysis results showed only the infection of hepatitisc (RR=2.86,95%CI:1.13-7.30,P=0.027),multiple tumor (RR=2.38,95%CI:1.39-4.07,P=0.002),diameter of tumor>5 cm (RR=2.13,95%CI:1.21-3.76,P=0.009), and lymph-vascular invasion(RR=1.96,95%CI:1.07-3.62,P=0.030) were the independent influencing factors of prognosis of the HCC patients.Conclusion The expression level of Galectin-9 is related to the tumor differentiation and lymph-vascular invasion of the HCC patients,and the expression levels of Galectin-3 and Galectin-9 are not associated with the prognosis  of HCC patients.

Key words:  , hepatocellular carcinoma, Galectin-3, Galectin-9, prognosis

中图分类号: 

  • R575