吉林大学学报(医学版) ›› 2015, Vol. 41 ›› Issue (05): 969-973.doi: 10.13481/j.1671-587x.20150516

• 临床研究 • 上一篇    下一篇

程序死亡性因子配体1蛋白表达与肺癌预后关联性的Meta分析

李时孟1, 潘宝香2, 李佟3, 谢风1, 王海1   

  1. 1. 吉林大学中日联谊医院检验科, 吉林 长春 130033;
    2. 吉林大学南湖校区医院口腔科, 吉林 长春 130012;
    3. 吉林大学中日联谊医院放射线科, 吉林 长春 130021
  • 收稿日期:2015-04-24 出版日期:2015-09-28 发布日期:2015-09-29
  • 通讯作者: 谢风,主任医师,教授,硕士研究生导师(Tel:0431-84995455,E-mail:xiefeng11@126.com);王海,副主任医师(Tel:0431-84995088,E-mail:13944170597@126.com) E-mail:xiefeng11@126.com;13944170597@126.com
  • 作者简介:李时孟(1990-),女,吉林省长春市人,在读医学硕士,主要从事临床检验在肿瘤诊断和预后中应用方面的研究。
  • 基金资助:

    吉林省科技厅国际合作资金项目资助课题(20140414005GH)

Correlation between expression of programmed cell death-ligand 1 protein and prognosis of lung cancer:A Meta-analysis

LI Shimeng1, PAN Baoxiang2, LI Tong3, XIE Feng1, WANG Hai1   

  1. 1. Department of Clinical Laboratory, China-Japan Union Hospital, Jilin University, Changchun 130033, China;
    2. Department of Stomatology, Nanhu Campus Hospital, Jilin University, Changchun 130012, China;
    3. Department of Radiology, China-Japan Union Hospital, Jilin University, Changchun 130021, China
  • Received:2015-04-24 Online:2015-09-28 Published:2015-09-29

摘要:

目的:采用Meta分析方法评价程序死亡性因子配体1(PD-L1)蛋白表达在肺癌预后评估中的价值,为肺癌预后评估提供依据。方法:计算机检索PubMed、EMbase、CNKI、中国期刊全文数据库和万方数据库中PD-L1与肺癌预后关联性的回顾性队列研究,采用文献追溯方法查找相关文献。检索时间从建库至2014年11月。由2名评价者按纳入和排除标准独立选择文献、提取资料和评价质量。采用Stata 11.0统计软件进行Meta分析,采用Begg's漏斗图和Egger's法评估文献的发表偏倚。结果:最终纳入9个队列研究、共1 306例肺癌患者进行Meta分析,PD-L1蛋白表达水平与肺癌预后无明显关联(HR=1.28,95%CI:0.78~2.09)。亚组分析,中国患者中PD-L1蛋白高表达者的死亡风险更高(HR=2.31,95%CI:1.73~3.10)。结论:中国肺癌患者中PD-L1蛋白高表达是肺癌预后的危险因素。

关键词: 肺肿瘤, 程序死亡性因子配体1, 预后, 生存率, Meta分析

Abstract:

Objective To explore the value of the expression of programmed cell death-ligand 1(PD-L1) protein in evaluation on the prognosis of lung cancer,and to provide the basis for evaluation on the prognosis of lung cancer. Methods PubMed,EMbase,CNKI and WanFang database were searched for collecting retrospective cohort studies on the relationship between of PD-L1 expression and the lung cancer,and the relevant articles were also retrieved from inception to November 2014. Two reviewers independently screened the articles,extracted the data and evaluated the quality.The results of Meta-analysis were analyzed by Stata 11.0 software,and the publication bias of paper was evaluated by means of Begg's funnel plot and Egger's methods. Results Finally 9 cohort studies involving 1 306 patients were included.The Meta-analysis results showed that there was no correlation between the PD-L1 protein expression and the prognosis of the patients with lung cancer(HR=1.28,95%CI:0.78-2.09). Then subgroup analyses results showed that high level of PD-L1 led to poor overall survival in Chinese patients(HR=2.31,95%:1.73-3.10). Conclusion High level of PD-L1 protein expression is the risk factor of lung cancer prognosis in the Chinese patients.

Key words: lung neoplasms, programmed cell death-ligand 1, prognosis, survival rate, Meta-analysis

中图分类号: 

  • R734.2