三磷酸腺苷负荷心肌灌注显像在女性冠心病患者诊断中的价值

doi:10.13481/j.1671-587x.20160234

吉林大学学报(医学版) ›› 2016, Vol. 42 ›› Issue (02): 370-374.doi: 10.13481/j.1671-587x.20160234

三磷酸腺苷负荷心肌灌注显像在女性冠心病患者诊断中的价值

姜文平¹, 侯森², 林秋玉², 谷瓅¹, 赵红光²

1. 吉林油田总医院核医学科, 吉林松原 138006;
2. 吉林大学第一医院核医学科, 吉林长春 130021

收稿日期:2015-07-15 发布日期:2016-03-31
通讯作者: 赵红光,主治医师(Tel:0431-88782766,E-mail:zhaohg@jlu.edu.cn) E-mail:zhaohg@jlu.edu.cn
作者简介:姜文平(1981-),女,吉林省白山市人,主治医师,医学硕士,主要从事核素影像学诊断方面的研究。
基金资助:
卫生部吴阶平医学基金资助课题(320675007127)

Value of adenosine triphosphate stressand rest nuclide myocardial perfusion imaging in diagnosis of female patients with coronary heart disease

JIANG Wenping¹, HOU Sen², LIN Qiuyu², GU Li¹, ZHAO Hongguang²

1. Department of Nuclear Medicine, Jilin Oilfield General Hospital, Songyuan 138006, China;
2. Department of Nuclear Medicine, First Hospital, Jilin University, Changchun 130021, China

Received:2015-07-15 Published:2016-03-31

摘要/Abstract

摘要：

目的: 评价三磷酸腺苷(ATP)负荷/静息核素心肌灌注显像(MPI)在女性冠心病(CHD)患者诊断中的价值。方法: 回顾性分析47例疑似CHD女性患者的临床资料。所有患者均入院接受二日法ATP负荷/静息核素MPI和冠状动脉造影(CAG)检查,2项检查均在2周内完成,每项检查结果均有2名以上的主治医师共同阅片。以CAG结果为"金标准",评价MPI对CHD的诊断效能(灵敏度、特异度和准确度)。结果: 与CAG结果比较,ATP负荷MPI对女性CHD患者的诊断灵敏度、特异度、准确度分别为81.3%(13/16)、77.4%(24/31)和78.7%(37/47);阳性预测值和阴性预测值分别为65.0%(13/20)和88.9%(24/27)。ATP负荷试验时不良反应的发生率为85.1%(40/47),无严重不良反应发生。结论: ATP负荷MPI对CHD患者具有较高的诊断效能,可作为女性CHD患者首选的无创性筛选与诊断心肌缺血的检查方法。

关键词: 三磷酸腺苷, 心肌灌注显像, 冠心病, 女性

Abstract:

Objective: To evaluate the value of adenosine triphophate (ATP) stress/rest nuclide myocardial perfusion imaging(MPI) in the diagnosis of female patients with coronary heart disease(CHD).Methods: The clinical materials of 47 female suspected CHD patients were retrospectively analyzed, aged from 39 to 74 years, and the average age was (53.7±6.3) years old.All patients were hospitalized and underwent two-day ATP stress and rest nuclide MPI and coronary angiography(CAG) in two weeks.The results and images of MPI and CAG were evaluated by more than 2 attending physicians.Using CAG as the "gold standard", the diagnostic efficiency (sensitivity, specificity and accuracy) of MPI for CHD was evaluated.Results: Compared with CAG, the sensitivity, specificity and accuracy of ATP stress MPI in diagnosing the female CHD patients were 81.3%(13/16), 77.4%(24/31)and 78.7%(37/47) individually;the positive predictive value and negative predictive value were 65.0%(13/20)and 88.9%(24/27).There were no severe adverse effects in the ATP stress test and the incidence of adverse effects was 85.1%.Conclusion: There is a highly diagnostic efficiency of ATP stress MPI in the CHD patients.It can be the first choice of examination methods for screening without injury and diagnosing the myocardial ischemia in the female patients.

Key words: adenosine triphosphate, myocardial perfusion imaging, coronary heart disease, female

中图分类号:

R817.4

姜文平, 侯森, 林秋玉, 谷瓅, 赵红光. 三磷酸腺苷负荷心肌灌注显像在女性冠心病患者诊断中的价值[J]. 吉林大学学报(医学版), 2016, 42(02): 370-374.

JIANG Wenping, HOU Sen, LIN Qiuyu, GU Li, ZHAO Hongguang. Value of adenosine triphosphate stressand rest nuclide myocardial perfusion imaging in diagnosis of female patients with coronary heart disease[J]. Journal of Jilin University Medicine Edition, 2016, 42(02): 370-374.

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三磷酸腺苷负荷心肌灌注显像在女性冠心病患者诊断中的价值

Value of adenosine triphosphate stressand rest nuclide myocardial perfusion imaging in diagnosis of female patients with coronary heart disease

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