结直肠息肉患者发病相关危险因素分析

doi:10.13481/j.1671-587x.20180336

摘要/Abstract

摘要： 目的：探讨性别、年龄、血脂水平对结直肠息肉发病的影响，阐明结直肠息肉发病的危险因素，为结直肠息肉临床诊疗提供参考。方法：检测结直肠息肉患者（息肉组，n=239）与同期结肠镜检查正常或为慢性非特异性肠炎患者（对照组，n=245）的血脂水平。分析性别、年龄和血脂水平对结直肠息肉发病的影响，检测不同发病部位、不同病理类型结直肠息肉患者血脂水平并进行比较。结果：高水平的低密度脂蛋白胆固醇（LDL-C）（P<0.01，OR=6.26，95%CI：3.79~10.33）、高水平甘油三酯（TG）（P=0.043，OR=1.63，95%CI：1.02~2.63）、男性（P=0.001，OR=2.05，95%CI：1.35~3.11）及年龄大于66岁的高龄患者（P=0.005，OR=1.90，95%CI：1.21~2.98）结直肠息肉发病率明显升高，2组研究对象高密度脂蛋白胆固醇（HDL-C）和总胆固醇（TC）水平比较差异无统计学意义（P>0.05）。左半结肠息肉患者LDL-C水平（t=-4.497，P<0.01）、TG水平（t=-2.116，P=0.036）、TC水平（t=-3.843，P<0.001）及高脂血症（HLP）比例（χ²=9.458，P=0.002）明显高于右半结肠息肉患者，而2组患者性别、年龄和HDL-C水平比较差异无统计学意义（P>0.05）。非腺瘤性结直肠息肉患者LDL-C水平高于腺瘤性大肠息肉患者（t=2.049，P=0.042），而2组患者性别、年龄、HDL-C水平、TG水平、TC水平及HLP比例比较差异无统计学意义（P>0.05）。结论：男性、高龄、高水平LDL-C及高水平TG是结直肠息肉发病的独立危险因素，LDL-C水平升高与非腺瘤性结直肠息肉发病有关联。

关键词: 低密度脂蛋白胆固醇, 高密度脂蛋白胆固醇, 甘油三酯, 结直肠息肉, 高脂血症

Abstract: Objective: To investigate the effects of gender,age,and blood lipid levels on the incidence of colorectal polyps,and to clarify the risk factors of colorectal polyps,and to provide the reference for clinical diagnosis and treatment of colorectal polyps. Methods: The serum lipid levels of the patients with colorectal polyps (polyps group,n=239) and the healthy controls or the patients with chronic nonspecific enteritis (control group,n=245) were examined.The effects of gender, age and blood lipid level on the incidence of colorectal polyps were analyzed,and the levels of blood lipids of the colorectal polyps patients with different pathogenesis parts and pathological types were detected and compared. Results: The incidence of colorectal polyps of the patients with high level of low density lipoprotein cholesterol(LDL-C) (P<0.01,OR=6.26,95%CI:3.79-10.33) and high level of triglyceride(TG)(P=0.043,OR=1.63,95%CI:1.02-2.63) and male (P=0.001,OR=2.05,95%CI:1.35-3.11) and the patients whose ages were older than 66 years old were increased. There were no significant differences in the levels of high density lipoprotein cholesterol(HDL-C) and total cholesterol (TC) of the patients between two groups (P>0.05).The levels of LDL-C(t=-4.497,P<0.01),TG (t=-2.116,P=0.036),TC (t=-3.843,P<0.01) and ratio of hyperlipidaemia(HLP) (χ²=9.458,P=0.002)in the patients with left colorectal polyps were higher than those in the patients with right colorectal polyps;but there were no significant differences in the gender,age and HDL-C level of the patients in these two groups (P>0.05).The level of LDL-C of the patients with non-adenomatous colorectal polyps was higher than that of the patients with adenomatous colorectal polyps (t=2.049,P=0.042);but there were no statistically significances in the gender,age and HDL-C level,TG level,TC level, and HLP ratio of the patients between two groups(P>0.05). Conclusion: Male,older,high levels of LDL-C and TG are the independent risk factors for colorectal polyps.High level of LDL-C is associated with non-adenomatous colorectal polyps.

Key words: low density lipoprotein, colorectal polyps, high density lipoprotein, total cholesterol, hyperlipidaemia, triglycerides

中图分类号:

R574.6

李佳, 杨落落, 周长丽, 何平, 孙逊, 孟祥伟. 结直肠息肉患者发病相关危险因素分析[J]. 吉林大学学报(医学版), 2018, 44(03): 646-650.

LI Jia, YANG Luoluo, ZHOU Changli, HE Ping, SUN Xun, MENG Xiangwei. Analysis on risk factors related to incidence of patientswithcolorectal polyps[J]. Journal of Jilin University Medicine Edition, 2018, 44(03): 646-650.

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