肿瘤相关巨噬细胞在口腔鳞状细胞癌发生发展中作用及其靶向治疗的研究进展

doi:10.13481/j.1671-587x.20180343

摘要/Abstract

摘要： 肿瘤相关巨噬细胞（TAMs）在口腔鳞状细胞癌（OSCC）发生发展过程中扮演重要角色。根据功能表型不同将TAMs分为M1型和M2型。M1型TAMs通过产生各种促炎因子参与炎症、清除体内病原体、参与抗肿瘤免疫而具有抗肿瘤作用，而M2型TAMs产生各种抗炎细胞因子来抑制炎症进而促进肿瘤的发生发展。大多数TAMs是M2样表型，其为OSCC的发生发展提供了有利的微环境，所以靶向TAMs在未来可成为一种新的治疗OSCC的方法。本文主要对TAMs在OSCC侵袭转移、血管生成中的作用和靶向TAMs治疗OSCC进行综述。

中图分类号:

R739.8

李波, 刘可可, 段浩博, 王远萍, 唐思嘉, 周乐, 孙宏晨. 肿瘤相关巨噬细胞在口腔鳞状细胞癌发生发展中作用及其靶向治疗的研究进展[J]. 吉林大学学报(医学版), 2018, 44(03): 684-688.

参考文献

[1] He KF,Zhang L,Huang CF,et al. CD163+ tumor-associated macrophages correlated with poor prognosis and cancer stem cells in oral squamous cell carcinoma[J]. Biomed Res Int,2014,2014:838632.
[2] Petruzzi MN,Cherubini K,Salum FG,et al.Role of tumour-associated macrophages in oral squamous cells carcinoma progression:an update on current knowledge[J].Diagn Pathol,2017,12(1):1-7.
[3] Ramanathan S,Jagannathan N.Tumor associated macrophage:a review on the phenotypes,traits and functions[J].Iran J Cancer Prev,2014,7(1):1-8.
[4] Dayan D,Salo T,Salo S,et al.Molecular crosstalk between cancer cells and tumor microenvironment components suggests potential targets for new therapeutic approaches in mobile tongue cancer[J].Cancer Med,2012,1(2):128-140.
[5] Costea DE,Hills A,Osman AH,et al.Identification of two distinct carcinoma-associated fibroblast subtypes with differential tumor-promoting abilities in oral squamous cell carcinoma[J].Cancer Res,2013,73(13):3888-3901.
[6] Noy R,Pollard JW.Tumor-Associated Macrophages:From Mechanisms to Therapy[J].Immunity,2014,41(1):49-61.
[7] Traves PG,Luque A,Hortelano S.Macrophages,inflammation,and tumor suppressors:ARF,a new player in the game[J].Mediators Inflamm,2012,2012:568783.
[8] Gabrilovich DI,Ostrand-Rosenberg S,Bronte V.Coordinated regulation of myeloid cells by tumours[J].Nat Rev Immunol,2012,12(4):253-268.
[9] Engblom C,Pfirschke C,Pittet MJ.The role of myeloid cells in cancer therapies[J].Nat Rev Cancer,2016,16(7):447-462.
[10] Ostuni R,Kratochvill F,Murray PJ,et al.Macrophages and cancer:from mechanisms to therapeutic implications[J].Trends Immunol,2015,36(4):229-239.
[11] Qian BZ,Pollard JW.Macrophage diversity enhances tumor progression and metastasis[J].Cell,2010,141(1):39-51.
[12] Komohara Y,Horlad H,Ohnishi K,et al.Importance of direct macrophage-Tumor cell interaction on progression of human glioma[J].Cancer Sci,2012,103(12):2165-2172.
[13] Lee H,Deng J,Kujawski M,et al.STAT3-induced S1PR1 expression is crucial for persistent STAT3 activation in tumors[J].Nat Med,2010,16(12):1421-U1105.
[14] Takeya M,Komohara Y.Role of tumor-associated macrophages in human malignancies:friend or foe?[J].Pathol Int,2016,66(9):491-505.
[15] Maniecki MB,Etzerodt A,Ulhoi BP,et al.Tumor-promoting macrophages induce the expression of the macrophage-specific receptor CD163 in malignant cells[J].Int J Cancer,2012,131(10):2320-2331.
[16] Richards DM,Hettinger J,Feuerer M.Monocytes and macrophages in cancer:development and functions[J].Cancer Microenviron,2013,6(2):179-191.
[17] De Palma M,Lewis CE.Macrophage regulation of tumor responses to anticancer therapies[J].Cancer Cell,2013,23(3):277-286.
[18] Medrek C,Ponten F,Jirstrom K,et al.The presence of tumor associated macrophages in tumor stroma as a prognostic marker for breast cancer patients[J].BMC Cancer,2012,12(1):1-9.
[19] Lotfi A,Mohammadi G,Tavassoli A,et al.Serum levels of MMP9 and MMP2 in patients with oral squamous cell carcinoma[J].Asian Pac J Cancer Prev,2015,16(4):1327-1330.
[20] Fan HX,Li HX,Chen D,et al.Changes in the expression of MMP2,MMP9,and ColIV in stromal cells in oral squamous tongue cell carcinoma:relationships and prognostic implications[J].J Exp Clin Cancer Res,2012,31:90.
[21] Fan HX,Wang S,Zhao H,et al.Sonic hedgehog signaling may promote invasion and metastasis of oral squamous cell carcinoma by activating MMP-9 and E-cadherin expression[J].Med Oncol,2014,31(7):41.
[22] Yu H,Lee H,Herrmann A,et al.Revisiting STAT3 signalling in cancer:new and unexpected biological functions[J].Nat Rev Cancer,2014,14(11):736-746.
[23] Fujiwara Y,Takeya M,Komohara Y.A novel strategy for inducing the antitumor effects of triterpenoid compounds:blocking the protumoral functions of tumor-associated macrophages via STAT3 inhibition[J].Biomed Res Int,2014,2014:348539.
[24] Bu LL,Yu GT,Deng WW,et al.Targeting STAT3 signaling reduces immunosuppressive myeloid cells in head and neck squamous cell carcinoma[J].Oncoimmunology,2016,5(5):e1130206.
[25] Cui R,Yue W,Lattime EC,et al.Targeting tumor-associated macrophages to combat pancreatic cancer[J].Oncotarget,2016,7(31):50735-50754.
[26] Riabov V,Gudima A,Wang N,et al.Role of tumor associated macrophages in tumor angiogenesis and lymphangiogenesis[J].Front Physiol,2014,5:75.
[27] Whipple C,Korc M.Targeting angiogenesis in pancreatic cancer:rationale and pitfalls[J].Langenbecks Arch Surg,2008,393(6):901-910.
[28] Matsumoto S,Saito K,Takakusagi Y,et al.In vivo imaging of tumor physiological,metabolic,and redox changes in response to the anti-angiogenic agent sunitinib:longitudinal assessment to identify transient vascular renormalization[J].Antioxid Redox Signal,2014,21(8):1145-1155.
[29] Kitamura T,Pollard JW.Therapeutic potential of chemokine signal inhibition for metastatic breast cancer[J].Pharmacol Res,2015,100:266-270.
[30] Yoshimura T,Howard OM,Ito T,et al.Monocyte chemoattractant protein-1/CCL2 produced by stromal cells promotes lung metastasis of 4T1 murine breast cancer cells[J].PLoS One,2013,8(3):e58791.
[31] Redon CE,Dickey JS,Nakamura AJ,et al.Tumors induce complex DNA damage in distant proliferative tissues in vivo[J].Proc Natl Acad Sci U S A,2010,107(42):17992-17997.
[32] Pena CG,Nakada Y,Saatcioglu HD,et al.LKB1 loss promotes endometrial cancer progression via CCL2-dependent macrophage recruitment[J].J Clin Invest,2015,125(11):4063-4076.
[33] Mok S,Koya RC,Tsui C,et al.Inhibition of CSF-1 receptor improves the antitumor efficacy of adoptive cell transfer immunotherapy[J].Cancer Res,2014,74(1):153-161.
[34] Yang CY,Lin CK,Lin GJ,et al.Triptolide represses oral cancer cell proliferation,invasion,migration,and angiogenesis in co-inoculation with U937 cells[J].Clin Oral Invest,2017,21(1):419-427.
[35] 马海龙,钟来平,张志愿.血管内皮细胞生长因子在口腔鳞状细胞癌进展和预后中的作用研究进展[J].中国口腔颌面外科杂志,2014,2(2):175-178.
[36] 郭伟.晚期口腔颌面-头颈部鳞癌靶向治疗的进展浅析[J].口腔颌面外科杂志,2012,22(2):77-81.
[37] Tymoszuk P,Evens H,Marzola V,et al.In situ proliferation contributes to accumulation of tumor-associated macrophages in spontaneous mammary tumors[J].Eur J Immunol,2014,44(8):2247-2262.
[38] Shiao SL,Ruffell B,DeNardo DG,et al.TH2-Polarized CD4(+) T Cells and Macrophages Limit Efficacy of Radiotherapy[J].Cancer Immunol Res,2015,3(5):518-525.
[39] Huang Z,Yang Y,Jiang Y,et al.Anti-tumor immune responses of tumor-associated macrophages via toll-like receptor 4 triggered by cationic polymers[J].Biomaterials,2013,34(3):746-755.
[40] Jia XH,Du Y,Mao D,et al.Zoledronic acid prevents the tumor-promoting effects of mesenchymal stem cells via MCP-1 dependent recruitment of macrophages[J].Oncotarget,2015,6(28):26018-26028.
[41] Tsagozis P,Eriksson F,Pisa P.Zoledronic acid modulates antitumoral responses of prostate cancer-tumor associated macrophages[J].Cancer Immunol Immunother,2008,57(10):1451-1459.
[42] Zhang X,Tian W,Cai X,et al.Hydrazinocurcumin Encapsuled nanoparticles "re-educate" tumor-associated macrophages and exhibit anti-tumor effects on breast cancer following STAT3 suppression[J].PLoS One,2013,8(6):e65896.
[43] Rolny C,Mazzone M,Tugues S,et al.HRG inhibits tumor growth and metastasis by inducing macrophage polarization and vessel normalization through downregulation of PlGF[J].Cancer Cell,2011,19(1):31-44.
[44] Dominguez-Soto A,de las Casas-Engel M,Bragado R,et al.Intravenous immunoglobulin promotes antitumor responses by modulating macrophage polarization[J].J Immunol,2014,193(10):5181-5189.