关键词: 铬, 血糖, 抗氧化剂, 糖尿病, 实验性

Abstract: Objective To study the effects of zinc and chromium on declining blood glucose level and improving antioxidant activity in diabetic mice. Methods The models of experimental diabetic mice were established by abdominal cavity injection of alloxan with the dose of 200 mg·kg^-1 . The mice were divided into 4 groups: zinc, chromium, normal control and experimental control group. The mice in zinc and chromium groups were respectively administered orally with ZnSO₄ and CrCl3 solution with the dose of 5.1 mg·kg ^-1·d^-1(Zn²⁺) and 40 μg·kg^-1·d^-1(Cr³⁺). Xanthine-oxidasemeasurement method was used to measure the quantity of SOD in hepatic tissues. Colorimetric method was used to measure the activities of GSH-Px and T-AOC in hepatic tissues. Thio-barbituric acid was used to measure the level of MDA. After four weeks, blood glucose, T-AOC, MDA, SOD, GSH-PX were detected. Results Compared with experimental group, blood glucose levels in zinc and chromium groups were decreased（P<0.01）, the activities of SOD and GSH-Px as well as T-AOC were increased（P<0.05 or P<0.01）. Meanwhile, the level of MDA was declined remarkably（P<01）. Compared with normal control group, the activities of SOD, GSH-Px and T-AOC were decreased (P<0.01）. Conclusion Zinc and chromium can decrease the blood glucose and improve the antioxidant activity in diabetic mice.

Key words: chromium, blood glucose, antioxidants, diabetic mellitus, experimental