关键词: 人类冠状病毒HKU1, 非霍奇金淋巴瘤, 第二代测序技术, 肺泡灌洗液

Abstract:

Objective To analyze the clinical manifestations， diagnostic methods and treatment process of the patients with non-Hodgkin’s lymphoma complicated with human coronavirus（HCoV）-HKU1 pneumonia and improve the clinical medical staff’s awareness of the disease， and to reduce the occurrence of clinical adverse events. Methods The clinical data of a patient with non-Hodgkin’s lymphoma complicated with HCoV-HKU1 pneumonia with hot flashes and night sweats， dry cough and dry throat as the main clinical features who were hospitalized in the hospital in January 2021 were analyzed， and the relevant literatures were reviewed and the clinical manifestations and diagnosis of HCoV-HKU1 were analyzed. Results The female patient was admitted to the hospital due to diagnosed non-Hodgkin’s lymphoma for more than 2 months. The physical examination results showed Karnofsky score was 90 points； there was no palpable enlargement of systemic superfical lymph nodes； mild tenderness in the right lower abdomen， no rebound tenderness，and slightly thicker breath sounds in both lungs were found， and a few moist rales were heard in both lower lungs. The chest CT results showed diffuse exudative foci in both lungs，and the number of white blood cells in the urine analysis was 158 μL^－1； next generation sequencing technique（NGS） was used the detect the bronchoalveolar lavage fluid，and HCoV-HKU1 pneumonia was diagnosed. At admission， the patient had symptoms such as dull pain in the right lower abdomen， nighttime cough， and night sweats； antiviral treatment with oseltamivir was ineffective. After treatment with Compound Sulfamethoxazole Tablets and Lianhua Qingwen Granules， the respiratory symptoms of the patient disappeared. The re-examination chest CT results showed the exudation was absorbed. Conclusion The clinical symptoms of the patients with non-Hodgkin’s lymphoma complicated with HCoV-HKU1 pneumonia are non-specific. When the diffuse shadow changes in the lungs are found in clinic， and the new coronavirus nucleic acid test is negative， attention should still be paid to the possibility of other HCoV infections. The NGS can efficiently screen the infectious pathogens， which is beneficial to guide the diagnosis and treatment of pulmonary infectious diseases more accurately.

Key words: Human coronavirus HKU1, Non-Hodgkin’s lymphoma, Next generation sequencing, Bronchoalveolar lavage fluid