人工骨质材料的生物学特性

doi:国家自然科学基金资助课题(20171010)

人工骨质材料的生物学特性

陈丙年¹, 李智¹,王宏芳², 李娟^2*

1 厦门大学医院外科，福建厦门361005；2 吉林大学公共卫生学院卫生化学教研室, 吉林长春130021

收稿日期:2005-12-21 修回日期:1900-01-01 出版日期:2006-07-28 发布日期:2006-07-28
通讯作者: 李娟

Biological characteristics of artificial bones

CHENG Bing-nian¹，LI Zhi¹，WANG Hong-fang²，LI Juan^2*

1. Deparment of Surgery,Hospital of Xiamen University, Xiamen 361005, China;2. Department of Hygienic Chemistry, Schoolof Public Health, Jilin University, Changchun 130021, China

Received:2005-12-21 Revised:1900-01-01 Online:2006-07-28 Published:2006-07-28
Contact: LI Juan

摘要/Abstract

摘要： 目的：制备表征多金属氧酸盐(POMs)纳米粒子掺杂的羟基磷灰石骨替代材料，并对其性能进行探讨。方法：用小鼠和白化兔，通过急性毒性实验、热原实验、皮内实验进行生物相容性检验。结果：材料为棒状，平均粒径为20 nm, 长度为100 nm左右。尺寸与人骨更接近，且POMs纳米粒子掺杂的壳聚糖/羟基磷灰石(CS/nano-HAP)复合材料无热原性，无毒，受试材料浸提液无刺激性。结论：此多金属氧酸盐纳米粒子掺杂的羟基磷灰石骨替代材料具有良好的生物相容性。这种材料与骨组织结合是一种骨性结合，具有较高的界面强度。

关键词: 骨代用品, 多金属氧酸盐, 生物相容性材料

Abstract: Objective To synthesize a novel polymer POMs-CS/nano-HAP and study its biocompatibility and safety. Methods The biocompatibility was evaluated through the experiments including acute systemic toxicity test, pyrogen, intracutaneous test. Results The crystals of POMs-CS/nano-HAP were equal on sizes, which average diameter was 20 nm and length was 100 nm. By comparing, the polymer were better than those reported, which were closer to the natural bone. The material had no toxicity, no irritation to skin. Conclusion The POMs-CS/nano-HAP artificial bone possesses excellent biocompatibility.

Key words: bone substitutes, polyoxometalates, biocompatible materials

中图分类号:

R73-361

陈丙年, 李智,王宏芳, 李娟. 人工骨质材料的生物学特性[J]. J4, 2006, 32(4): 571-574.

CHENG Bing-nian，LI Zhi，WANG Hong-fang，LI Juan. Biological characteristics of artificial bones[J]. J4, 2006, 32(4): 571-574.

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