转化生长因子-β1在实验性根尖周炎病

doi:吉林省科技厅科研基金资助课题（970568-2）

转化生长因子-β₁在实验性根尖周炎病

张颖丽^1*，黄洋¹，张英杰²，张天夫²

1.　吉林大学口腔医院牙体牙髓病科，吉林长春130041；2. 吉林大学中日联谊医院口腔科，吉林长春130033

收稿日期:2006-01-11 修回日期:1900-01-01 出版日期:2006-09-28 发布日期:2006-09-28
通讯作者: 张颖丽

Expression of TGF-β₁ on experimental periapical lesions in rats and its significance

ZHANG Ying-li^1*,HUANG Yang¹, ZHANG Ying-jie², ZHANG Tian-fu²

1.　Department of Endodontics, Stomatology Hospital, Jilin University, Changchun 130021,China;2. Department of Stomatology，China-Japan Union Hospital, Jilin University, Changchun 130033,China

Received:2006-01-11 Revised:1900-01-01 Online:2006-09-28 Published:2006-09-28
Contact: ZHANG Ying-li

摘要/Abstract

摘要： 目的：探讨转化生长因子-β₁(TGF-β₁)在实验性根尖周病炎症反应和预防中的可能作用。方法：30只Wistar大鼠于上颌1、2磨牙制备根尖周炎动物模型（实验组），下颌1、2磨牙作自身对照组。按开髓后1~10周不同时间点随机分成10组(n=3)，采用组织病理学及免疫组织化学方法观察TGF-β₁在根尖周炎病变不同阶段中的定位及分布。结果：实验组炎症早期的牙髓（第1~2周）和根尖周（第4~6周）组织中均可见TGF-β₁阳性表达，表达细胞多为巨噬细胞、淋巴细胞和成纤维细胞；其染色强度随炎症的发展而改变；牙髓坏死及根尖周炎慢性期（第7周）TGF-β₁阳性表达消失。自身对照组下颌第1、2磨牙不同时间点牙髓及根尖部组织均未见TGF-β₁阳性染色。结论：TGF-β₁在实验性根尖周病变的炎症反应和防御反应中具有一定的调节作用。

关键词: 根尖周炎

Abstract: Objective To observe the distribution and location of TGF-β₁ in different stages of experimental lesions and to discuss its potential function.Methods Thirty Wistar rats were established experimental periapical lesions in maxillary first and second molar as experimental group while mandibular molar as control group, and they were divided into ten groups by the time（1，2，3，4，5，6，7，8，9, and 10 weeks）after pulp exposure, three rats in everygroup. Expression of TGF-β₁ was detected by histopathology and immunohistochemistry.Results Strong expression of TGF-β₁ was observedin acute inflammation of pulp (1st-2nd week) and periapical tissue (4th-6th week), and idisappeared in pulp aecrosis and in chronic inflammation of periapical tissue(7th week). The main cells expressing TGF-β₁ were macrophage，lymphocyte and fibroblast. Conclusion TGF-β₁ has the certain function in inflammation and prevention of experimental periapical lesions.

Key words: periapical periodontitis

中图分类号:

R781.341

张颖丽，黄洋，张英杰，张天夫. 转化生长因子-β₁在实验性根尖周炎病[J]. J4, 2006, 32(5): 794-796.

ZHANG Ying-li,HUANG Yang, ZHANG Ying-jie, ZHANG Tian-fu. Expression of TGF-β₁ on experimental periapical lesions in rats and its significance[J]. J4, 2006, 32(5): 794-796.

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转化生长因子-β₁在实验性根尖周炎病

Expression of TGF-β₁ on experimental periapical lesions in rats and its significance

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