扁桃体原发性恶性淋巴瘤的免疫病理学特征

J4 ›› 2011, Vol. 37 ›› Issue (6): 1106-1110.

扁桃体原发性恶性淋巴瘤的免疫病理学特征

刘学娟^1,2|杨华¹|王连友¹|钟艳平¹|孙大菊¹

1.吉林大学中日联谊医院病理科|吉林长春 130033；2.吉林大学白求恩医学院病理生物学教育部重点实验室|吉林长春 130021

收稿日期:2011-06-14 出版日期:2011-11-28 发布日期:2011-11-28
通讯作者: 杨华（Tel:0431-89876951,E-mail:pathyh2002@yahoo.com） E-mail:pathyh2002@yahoo.com
作者简介:刘学娟（1978-）|女|吉林省白山市人|主治医师|在读医学博士|主要从事干细胞组织工程研究。
基金资助:
卫生部科教司科研基金资助课题（1994-2-158）；吉林省长春市科技局科研基金资助课题（2001-086-510）

Immunopathological characteristics of tonsillar malignant lymphoma

LIU Xue-juan ^1,2,YANG Hua¹,WANG Lian-you¹| ZHONG Yan-ping ¹,SUN Da-ju¹

1.Department of Pathology,China-Japan Union Hospital,Jilin University,Changchun 130033,China2.Key Laboratory of Pathobiology,Ministry of Education,Jilin University,Changchun 130021,China

Received:2011-06-14 Online:2011-11-28 Published:2011-11-28

摘要/Abstract

摘要：

目的：探讨扁桃体原发性恶性淋巴瘤的类型特征和Ki-67、bcl-6及CD10的表达，阐明其生物学意义。方法：应用组织形态学和免疫组织化学方法，按照WHO造血和淋巴组织肿瘤第四版分类,复查50例扁桃体原发性恶性淋巴瘤的诊断并标记分类观察。结果：本组滤泡性淋巴瘤（FL ）37例，弥漫大B细胞淋巴瘤(DLBCL) 9例，伯基特淋巴瘤（BL）和外周T细胞淋巴瘤（PTCL）各2例。FL 1、2级为惰性淋巴瘤16例；Ki-67阳性在惰性淋巴瘤占25%（4/16），侵袭性占58.06%（18/31），Ki-67表达在不同恶性程度组间比较差异有统计学意义（P<0.05）；bcl-6 在88%(44/50)的扁桃体恶性淋巴瘤中不同程度表达。bcl-6+/bcl-2+在低级别FL中占40.00%（8/20），高级别中占61.89%（13/21），DLBCL 中占77.78%（7/9）；CD10表达在性别组间比较差异有统计学意义（P<0.05）。结论：本组病例均为非霍奇金恶性淋巴瘤；以FL为主，其次是DLBCL，而BL和PTCL少见；从低级别FL转变为高侵袭性DLBCL，Ki-67表达率有增高趋势；bcl-6在不同类型中表达不同，侵袭性淋巴瘤中的表达明显高于惰性淋巴瘤；bcl-6+/bcl-2+表达从FL低级别到高级别并向DLBCL转变过程中依次增高。

关键词: 恶性淋巴瘤；扁桃体肿瘤；免疫表型分型

Abstract:

Objective To study the subtypes of 50 cases of tonsillar malignant lymphoma and the expressions of Ki-67,bcl-6 and CD10 and explore their bilolgical significance.Methods By means of histomorphology and immunohistochemistry,50 cases of primary tonsillar biopsy were reviewed according to the new classification of WHO(2008). Results There were 37 cases of follicular lymphoma(FL), 9 cases of diffuse large B-cell lymphoma(DLBCL)，2 cases of Burkitt’s lymphoma(BL) and 2 cases of peripheral T-cell lymphoma(PTCL）,16 cases of FL grade 1 and 2. The expression of Ki-67 was in 25%（4/16） of the indolent lymphoma,and 58.06%（18/31） of the aggressive lymphoma.The Ki-67 expression showed significant difference between different grades of malignancy (P<0.05).The variable expression of bcl-6 was in 88%(44/50) of NHL of tonsil.Coexpression of bcl-2+ and bcl-6+ in 40%（8/20）of the low grade FL，61.89%（13/21） of the high grade FL and 77.78%（7/9）of DLBCL.The CD10 expression showed statistical significance between genders(P<0.05).Conclusion All the cases of tonsillar malignant lymphoma are non-Hodgkins lymphoma.The most histological subtypes is FL,in turn DLBCL,BL and PTCL.There is a rising tendency of Ki-67 expression from low grade FL to aggressive DLBCL.The expressions of bcl-6 vary in different subtypes such as FL，DLBCL，BL and PTCL.There is an increase trend of bcl-2+ and bcl-6+ coexprssions in low grade FL,high grade FL and DLBCL in sequence.

Key words: malignant lymphoma;tonsillar neoplasms;immunophenotyping

中图分类号:

R733.1

刘学娟|杨华|王连友|钟艳平|孙大菊. 扁桃体原发性恶性淋巴瘤的免疫病理学特征[J]. J4, 2011, 37(6): 1106-1110.

LIU Xue-juan,YANG Hua,WANG Lian-you| ZHONG Yan-ping,SUN Da-ju. Immunopathological characteristics of tonsillar malignant lymphoma [J]. J4, 2011, 37(6): 1106-1110.