关键词: 病理生理学, 血液动力学, 计算流体力学, 数值模拟, 切应力

Abstract: Objective To investigate the hemodynamic characteristics of intracranial terminal aneurysms and analysis the possible mechanism of growth and rupture of intracranial aneurysms. Methods Some images of intracranial terminal aneurysms were handled by some image processing software. The profile meshed by some computational fluid dynamics (CFD) software were used to simulate the flow and analysis wall shear stress. Results From the beginning to 0.22 T in every cardiac cycle, the wall shear stress had a change sharply to the maximum and then decreased dramatically to the zero from 0.22-0.55 T accompany with velocity. There were maximum stress and minimum stress when 0.22 T and 0.55T at neck, but meanwhile there was no wall shear stress at the wall. Conclusion Pressure is one of risk factors which will make the aneurysm rupture. CFD simulation can provide key hemodynamic information for pathophysiological mechanisms and clinical treatment of intracranial terminal aneurysms.

Key words: physiopathology, hemodynamics, compututional fluid dynamics, numerical simulation, shear stress