海洛因对脑及肌肉组织中腺苷脱氨酶含量的影响

doi:吉林省科技厅基金资助课题，吉林大学创新基

海洛因对脑及肌肉组织中腺苷脱氨酶含量的影响

程丕显¹，洪敏¹，杨宇丹¹，郭艳霞²,孙聪²

1.　吉林大学基础医学院生物化学与分子生物学教研室，吉林长春130021;2. 长春中医学院生物化学教研室，吉林长春130117

收稿日期:2004-10-15 修回日期:1900-01-01 出版日期:2005-05-28 发布日期:2005-05-28

Effects of heroin on concentrations of adenosine deaminase in brain and muscle tissues

CHENG Pi-xian¹，HONG Min¹，YANG Yu-dan¹，GUO Yan-xia²，SUN Cong²

1.　Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Jilin University, Changchun 130021, China;2. Department of Biochemistry, Changchun College of Traditional Chinese Medicine, Changchun 130117, China

Received:2004-10-15 Revised:1900-01-01 Online:2005-05-28 Published:2005-05-28

摘要/Abstract

摘要： 目的：检测海洛因给药、停药大鼠脑和肌肉组织中腺苷脱氨酶（ADA）含量，探讨海洛因给药对嘌呤核苷酸分解代谢的影响。方法：建立海洛因给药、停药大鼠模型，测定脑及肌肉组织中的ADA含量。结果：与对照组比较，给药3 d组大鼠脑和肌肉组织中ADA含量均有增高趋势（P>0.05），给药9 d组显著增高（P<0.05）。与给药9 d组比较，停药3 d组大鼠脑组织中ADA含量下降不显著，停药8 d组明显降低（P<0.01）；停药3 d组肌肉组织中ADA含量已明显低于给药9 d组（P<0.01），停药8 d组下降更为显著。结论：海洛因通过增加ADA的含量，使脑及肌肉组织中嘌呤核苷酸分解代谢增强，且脑组织中这一作用比肌肉组织更显著、持久。

关键词: 毒性, 腺苷脱氨酶, 嘌呤核苷酸类

Abstract: Objective To investigate the effects of heroin on purine nucleotides catabolism by testing the adenosine deaminase(ADA) concentrations in brain and muscle tissues in rats which were administrated with heroin. Methods The rat models of heroin administration and withdrawal were established. Concentrations of ADA in brain and muscle tissues were tested. Results When two heroin administration groups were compared with the control group, the ADA concentrations in brain and muscle tissues were increased in the 3-day heroin administration group（P>0.05）and the enhancement of the ADA concentration in the 9-day heroin administration group was more apparent（P<0.05）. When two withdrawal groups were compared with the 9-day heroin administration group, the ADA concentration in the brain wasn′t decreased apparently in the 3-day withdrawal group, while the brain ADA concentration in the 8-day withdrawal group was decreased significantly（P<0.01）. The muscle ADA concentration in the 3-day withdrawal group was already decreased （P<0.01） and the decrease of that in the 8-day withdrawal group was more significant. Conclusion The administration of heroin can enhance the catabolism of purine nucleotides in brain and muscle tissues by increasing the concentration of ADA and the effect may last for a long time in brain.

Key words: toxicity, adenosine deaminase, purine nucleotides

中图分类号:

R996

程丕显，洪敏，杨宇丹，郭艳霞,孙聪. 海洛因对脑及肌肉组织中腺苷脱氨酶含量的影响[J]. J4, 2005, 31(3): 384-386.

CHENG Pi-xian，HONG Min，YANG Yu-dan，GUO Yan-xia，SUN Cong. Effects of heroin on concentrations of adenosine deaminase in brain and muscle tissues[J]. J4, 2005, 31(3): 384-386.

[1]	何莲, 聂斌. PICCO和CVP监测在脓毒性休克并发心功能不全患者治疗中的应用价值[J]. 吉林大学学报(医学版), 2018, 44(05): 1030-1035.
[2]	史金先, 张赐童, 刘璐, 黄天意, 闫通通, 孙世群, 王晓容. 纳米载银室温固化型PMMA材料对小鼠肝组织和肝细胞DNA损伤的影响[J]. 吉林大学学报(医学版), 2018, 44(05): 962-967.
[3]	李玉佳, 卢伟, 杜侃. 磷酸肌酸钠联合利巴韦林治疗小儿病毒性心肌炎的临床疗效及其对患儿心肌酶水平的影响[J]. 吉林大学学报(医学版), 2018, 44(01): 137-141.
[4]	张帆, 郑逸, 杨晓红, 叶彩芬, 王良玉. 二维斑点追踪技术在评价蒽环类药物治疗恶性淋巴瘤继发心功能损害中的应用[J]. 吉林大学学报(医学版), 2017, 43(06): 1193-1198.
[5]	方艳秋, 米旭光, 李首庆, 魏海峰, 许淑芬, 谭岩. 重组鼠白细胞介素18在肝癌小鼠体内的抗肿瘤作用[J]. 吉林大学学报(医学版), 2017, 43(03): 550-554.
[6]	樊锐太, 张恒, 王鑫, 顾浩. 胶质瘤患者T淋巴细胞表面CTLA-4的表达及其临床意义[J]. 吉林大学学报(医学版), 2016, 42(02): 311-315.
[7]	黎萍, 郑百红, 陈鹏, 许忠, 张磊, 潘薇. 硒对病毒性心肌炎小鼠心肌细胞凋亡的抑制作用及其作用机制[J]. 吉林大学学报(医学版), 2016, 42(01): 54-58.
[8]	潘涛, 郭彩霞, 金明华, 刘晓梅, 刘颖, 杜海英, 孙志伟. 纳米二氧化硅颗粒对肝HL-7702细胞的毒性作用[J]. 吉林大学学报(医学版), 2015, 41(05): 885-890.
[9]	陈睿, 李雯娟, 杨凯, 王有为, 唐洪, 陈丹, 白云龙, 黄昊. RGD肽段连接的近红外量子点对小鼠的毒性作用[J]. 吉林大学学报(医学版), 2015, 41(04): 690-696.
[10]	耿维佳, 李阳, 于永波, 于洋, 段军超, 杨玉梅, 邹洋, 孙志伟. N-乙酰半胱氨酸对纳米二氧化硅所致细胞毒性的抑制作用[J]. 吉林大学学报(医学版), 2015, 41(03): 486-490.
[11]	夏银叶, 李艳博, 牛丕业, 王晖, 王翼飞, 梁宝璐, 赵峰, 郭彩霞, 孙志伟. 纳米二氧化硅颗粒对血管内皮细胞的毒性及其凋亡诱导作用[J]. 吉林大学学报(医学版), 2015, 41(03): 454-459.
[12]	逄紫千,叶玉琴,李秋明. 肌电图在糖尿病性周围神经病和酒精中毒性周围神经病诊断及鉴别诊断中的应用价值[J]. 吉林大学学报(医学版), 2014, 40(06): 1247-1251.
[13]	张晓燕，李正强，孙莹，王冠勋，郑璐,韩冰. 丝素蛋白/左旋聚乳酸复合组织工程纳米材料的生物相容性及安全性评价[J]. 吉林大学学报(医学版), 2014, 40(03): 578-582.
[14]	李艳博，周维，于永波，段军超，郭彩霞，孙志伟. 纳米二氧化硅颗粒对血管内皮细胞的毒性及其氧化损伤作用[J]. 吉林大学学报(医学版), 2014, 40(03): 476-481.
[15]	杜欧,盖丽婷,王民艳,姜秋. 聚乳酸/羟基磷灰石复合材料的机械性能及其细胞毒性[J]. 吉林大学学报(医学版), 2014, 40(02): 300-305.