关键词: 纤维蛋白原, 缺血性心脏病

Abstract: Objective To research the association of β-fibrinogen bcl-I polymorphisms and plasma fibrinogen level with the pathogenesis of ischemic heart disease. Methods 57 patients with myocardical infarction and 50 healthy controls were enrolled in this trail. The polymorphisms of β-fibrinogen bcl-I gene was detected by polymerase chain reaction-restriction fragment length polymorphisms (PCR-RFLP). Plasma fibrinogen levels were assayed by tissue thromboplastin. Results Two allele, B1 and B2, were found at 2 500 bp and 1 100 bp+1 400 bp，respectively. The plasma fibrinogen level, （3.28±0.94）g·L^-1, in patients with allele B1 was significantly higher than that in the healthy control subjects,（2.74±0.54）g·L^-1 （P<0.05）, as well as with allele B2（3.97±1.02）g·L^-1 vs（3.25±0.61）g·L^-1. The plasma fibrinogen level in the samples of genotype B2 was higher than thatin samples of B1（P<0.05）. The frequency of genotype B2 allele was higher in cases with myocardical infarction than that in healthy controls（P<0.05）. Conclusion There is significant association between the fibrinogen plasma level and myocardical infarction. β-fibrinogen bcl-I gene polymorphism is associated with plasma level of fibrinogen and myocardical infarction. These suggest that β-fibrinogen bcl-I gene polymorphism may be a risk factor and a susceptible predictor of ischemic heart disease.

Key words: fibrinogen, ischemic heart disease