乳腺癌患者血清中环氧化酶-2的表达及意义

J4 ›› 2010, Vol. 36 ›› Issue (6): 1118-1121.

乳腺癌患者血清中环氧化酶-2的表达及意义

王杨¹|刘敏²|王兆鹏³

1.吉林大学中日联谊医院特需病房, |吉林长春 130033; |2.承德医学院附属医院检验科| |河北承德 |067000； 3.承德医学院附属医院老年病科| |河北承德 |067000

收稿日期:2010-05-21 出版日期:2010-11-28 发布日期:2010-11-28
通讯作者: 王杨（Tel：0431-89876855，E-mail：wangyang@csco.org.cn） E-mail:wangyang@csco.org.cn
作者简介:王杨（1956-）|女|吉林省长春市人|教授|主要从事血液系统疾病及恶性肿瘤的诊治研究。
基金资助:
吉林省科技厅白求恩医学专项基金资助课题（200705290）

Expression of |serum cyclooxygenase-2 |in patients with breast cancer and its significance

WANG Yang¹, LIU Min², WANG Zhao-Peng³

1. |Department of |VIP,China-Japan Union Hospital,Jilin University,Changchun |130033,China;2. |Department of Laboratory,Affiliated |Hospital,Chengde Medical College,Chengde |067000 China;3. |Department of Gerontology,Affiliated |Hospital,Chengde Medical College,Chengde |067000 China

Received:2010-05-21 Online:2010-11-28 Published:2010-11-28

摘要/Abstract

摘要：

目的：检测乳腺癌患者术前及术后血清环氧化酶-2(COX-2)的水平，探讨COX-2与乳腺癌临床病理特征的关系。方法：采用酶联免疫吸附试验(ELISA法)检测乳腺癌组30例、腺病组13例及对照组13例血清COX-2水平，分析不同病理特征患者的血清COX-2表达水平。结果：乳腺癌术前及术后组患者血清COX-2水平均明显高于对照组和腺病组(P<0.01)；乳腺癌术前组患者血清COX-2水平明显高于术后组(P<0.01)。乳腺癌患者术前有淋巴结转移者血清COX-2水平高于无淋巴结转移患者(P<0.05)，ER阴性的患者血清COX-2水平明显高于ER性患者(P<0.01)，HER-2阳性患者血清COX-2水平明显高于HER-2阴性患者(P<0.01)。结论：乳腺癌患者血清中COX-2水平明显高于对照组及腺病组，血清COX-2水平的检测可作为乳腺癌诊断的一项筛选指标，也可用于鉴别乳腺良、恶性疾病。

关键词: 乳腺肿瘤;环氧化酶-2;酶联免疫吸附试验;临床病理特征

Abstract:

Abstract:Objective To detect the serum levels of cyclooxygenase-2(COX-2)in patients with breast cancer before and after operation,and approach the relation of COX-2 with the clinicopathological characteristics of breast cancer.Methods The serum COX-2 expression levels in 30 cases of breast cancer,13 cases of adenosis and 13 cases of controls were detected by enzyme-linked immunosorbent assay (ELISA).Results The serum levels of COX-2 in pre-operative group and post-operative group were significantly higher than those in control group and adenosis group (P<0.01).The serum level of COX-2 in patients with breast cancer in pre-operative group was higher than that in post-operative group (P<0.01),the serum level of COX-2 in patients with lymph node metastasis was significantly higher than that in patients without lymph node metastasis(P<0.05),ER-negative patients had higher level of serum COX-2 than ER positive patients (P<0.01),the serum COX-2 level in HER-2 positive patients was higher than that in negative patients(P<0.01).Conclusion The serum level of COX-2 in breast ancer patients is significantly higher than those in normal control group and breast adenosis group.Detection of the serum level of COX-2 in patients with breast cancer can be used as a candidate diagnostic indicator and for diagnos
is of the benign and malignant breast diseases.

Key words: breast neoplasms, cyclooxygenase-2;enzyme-linked immunosorbent assay; , clinicopathological characteristic

中图分类号:

R737.9

王杨, 刘敏, 王兆鹏. 乳腺癌患者血清中环氧化酶-2的表达及意义[J]. J4, 2010, 36(6): 1118-1121.

WANG Yang, LIU Min, WANG Zhao-Peng. Expression of |serum cyclooxygenase-2 |in patients with breast cancer and its significance[J]. J4, 2010, 36(6): 1118-1121.

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