关键词: 关节镜检查, 透明质酸钠, 白细胞介素1, 一氧化氮

Abstract: Objective To study the curative effect of arthroscopic debridement (AS) and intra-articular sodium hyaluronate injection for patients suffering from knee osteoarthritis (KOA) and explore their influences on the levels of interleukin-1 (IL-1) and nitric oxide(NO) in serum and synovial fluid. Methods 69 patients with grade Ⅰ to grade Ⅲ KOA were randomly divided into AS group (n=32) and SHI group (n=37). All of the cases were estimated by Lysholm scoring scale pre-intervetion and 1 year post-intervetion,and then serum and synovial fluid were collected to detect the levels of IL-1 and NO before and after therapy,respectively, with Nitrate reductase and enzyme-linked immuneoabsordent assay (ELISA). Results Lysholm scores in the two groups were significantly different between pre-operation and post-operation (P<0.05),and the rate of satisfaction one year post-operation in AS group was 78.0%, superior to 58.3% in SHI group.In addition,before therapy,levels of IL-1 and NO in synovial fluid were obviously higher than those in serum in KOA patients (P<0.05). There were significant differences of levels of IL-1 and NO in serum and synovial fluid between pre-operation and post-operation (P<0.05). Conclusion Both AS and SHI can increase the Lysholm score in KOA patlents,decrease the levels of IL-1 and NO in serum and synovial fluid. AS is superior to SHI in functional improvement.

Key words: arthroscopy, sadium hyaluronate, interleukin-1, nitric oxide