关键词: 铅暴露, 记忆能力, 可塑性, 代偿性

Abstract: Abstract:Objective To explore the effects of motion environment on memory capacity in low-level lead exposure mice and mechanism.Methods Healthy weaned male ICR mice were randomly divided into control group and experimental group (lead exposure group) and then every group was divided into 2 groups: common feeding group and common feeding plus motion group (n=10). The mice in experimental group were fed with 0.2％ low-level lead drinking water for 8 weeks. Luminosity test (using an atom to absorb a beam split),Morris water maze test and immune test were applied respectively to detect the levels of blood lead and hippocampus lead and the impact of lead on mouse space memory and the histological changes. Results The lead levels in blood and hippocampus in experimental group were significantly higher than those in control group (P<0.01). The lead level in hippocampus in common feeding group of experimental group was higher than that in common feeding plus motion group（P<0.05）. In space memory test,the latent time to reach refuge platform in common feeding group of experimental group was slower than that in control group (P<0.05),and it was higher in common feeding group of experimental group than that in common feeding plus motion group(P<0.05). The pathohistological results showed that focal necrosis was found in common feeding groups of experimental group,and focal uneven distribution,degeneration of never cells were found in common feeding plus motion group of experimental group . Conclusion The stimulation of motion environment can improve the ability of space memory and promote the hippocampus plasticity and compensatory in low-level lead exposure mice.

Key words: lead exposure, capacity of memory, plasticity, compensatory