Abstract:

Objective
To study the changes of the expressions of VEGF,bFGF and CD34 in vulvar white lesion tissues  before and after focusing ultrasound therapy and clarify the mechanism of focusing ultrasound in treatment of vulvar white lesion. Methods The expressions of  VEGF,bFGF and CD34 in 30 cases of vulvar white lesion tissues,15 cases one month after  treatment and 8 cases three months after  treatment were detected by  SP immunohistochemistry method. The positive expressions of VEGF,bFGF and CD34 in vulvar white lesion tissues in three groups before and after  treatment were compared.
Results The expressions of VEGF and bFGF in vulvar white lesion tissues after treatment were higher than before treatment(P<0.05).The expression of CD34 in vulvar white lesion tissues had no significant difference between before and after treatment (P>0.05). Conclusion Focusing ultrasound therapy could increase the expressions  of VEGF and bFGF in vulvar white lesion tissues and improve the structure and function of nerve and capillary.

Key words: high intensive focusing ultrasound;white lesions of vulva;vasular endothelial growth factor；basic fibroblast growth factor;CD 34