Abstract:

Abstract:Objective To evaluate the association of 5-hydroxytryptamine 1A receptor gene( 5-HT1A receptor gene) rs6295  polymorphism and suicide with Meta-analysis. Methods PubMed,Cochorane,CNKI and Wanfang Database were used to  search all the relevant case-control trials about the association of 5-HT1A receptor gene rs6295 polymorphism and suicide. Statistical analysis was performed with RevMan5.0 including the  heterogeneity inspection, effect consoliating and evaluatation on  publication bias. Results A total of 6 articles were included after the analysis.Because suicide in the literature included suicide attempters and suicide completers, 7 independent studies were selected. Overall the results of suicide genotype Meta analysis were listed as follows: OR=1.27，95 %CI=0.93-1.74,P>0.05，suicide alleles were  OR=1.15,95 %CI=0.91-1.45,P>0.05.The Meta analysis results of suicide attempter genotype  were listed as follows: OR=1.12,95 %CI=0.84-1.49,P>0.05;suicide attempter alleles  OR=1.04,95 %CI=0.87-1.24,P>0.05.The Meta analysis  results of suicide completer genotypes were listed as follows: OR=1.53,95 %CI=1.10-2.14,P<0.01,suicide completer alleles were OR=1.57,95 %CI=0.66-3.71，P>0.05.Conclusion The Meta analysis results show that the  5- HT1A receptor gene rs6295 polymorphisms are not associated with suicide attempters but associated with suicide completers.

Key words: suicide;5-hydroxytryptamine 1A receptor;polymorphism;Meta analysis