Abstract: Objective: To report one case of mushroom poisoning complicated with multiple organ disfunction syndrome treated by sequential blood purification,and to explore the treatment method and principle of mushroom poisoning complicated with multiple organ disfunction syndrome. Methods: Hemoperfusion was performed in the patient,once every other day,combined with sequential blood purification of hemoperfusion and hemodialysis, and supplemented by hormone therapy and anti-infection. Results: The patient was out of danger,and the vital signs were stable;liver function,kidney function and blood routine were recovered. Conclusion: Early application of hemoperfusion combined with sequential blood purification can effectively treat the mushroom poisoning complicated with multiple organ disfunction syndrome and thrombotic microangiopathy,and improve the prognosis.

Key words: sequential blood purification, thrombotic microangiopathy, mushroom poisoning, multiple organ disfunction syndrome