Abstract:

Abstract:Objective To evaluate the association between  brain lesion location and occurrence of poststroke depression  patients  (PSD) with acute stroke from Chinese people with Meta-analysis,and to provide evidence to explore mechanism of PSD.Methods Pubmed,CNKI,VIP and Wanfang databases were searched by computer to find literatures focused on associations between  lesion location and PSD from January 2000 to November 2011.Those met criterion were included in the study and  evaluated.The data in the articles was  extracted at the same time.ReviewManager 5.1 software was performed to analyze the data. Fix effect model and random effect model were used to calculate combined effects.Publish bias was evaluated and the sensitivity analysis was performed.Results Twenty-two articles were included in the study finally.In all,3 545 subjects included,which contained 1 493 PSD patients and 2 052 non-PSD persons.Combined OR and its 95% confidence interval which were used to evaluate associations between PSD and different   lesion location were as follows: left hemisphere 1.60(1.39-1.83) (P<0.001),front of brain 2.76(1.60-4.75) (P<0.001),frontal lobe 2.11(1.00-4.45) (P=0.05),and cortex 2.22(0.74-6.62) (P=0.15).Among acute stroke patients,those who suffered with their left hemisphere had 1.6 times higher risk to be PSD of those with right hemisphere injure;the patients who suffered with their front of brain had 2.76 times higher risk to be  PSD of those with back of brain injure.Conclusion The  lesion places  which located in left hemisphere and front of brain are the risk factors for PSD.

Key words: poststroke depression;lesion location;Meta-analysis