Abstract: Objective To study the anti-ageing and antioxidation of polyphends of vitis amurensis Rupr(PVAR).Methods Forty senile male Wistar rats (20 months) were divided into 4 goups according rats′ weights:senile negtive control group(A), fed with basic forage;two senile PVAR groups(B and C),fed with basic forage inchuding 200 and 400 mg•kg^-1•d^-1 PVAR;senile positive control(D), fed with basic forage inchuding 200 mg•kg^-1•d^-1 melissic powder.After fed continuously for 8 weeks,the MDA contents in RBC-membrane, plasma and liver,sulfhydryl content in RBC-membrane, sialic acid content,activity of Na⁺-K⁺-ATPasc,fluidity of RBC-membrane,and activity of plasma GSH-Px in rats were detected.Results Compared with group A,the contents of MDA in groups B,C,and D decreased significantly(P<0.05，P<0.01)；sulfhydryl contents in RBC-membrane and activities of plasma GSH-Px in group C and D increased significantly(P<0.05).There were no significant differences of various indexes between group B,C and group D (P<0.05).Conclusion PVAR has anti-ageing and antioxidation on senile rats.

Key words: phends, pharmacology, ageing, antioxidation, erythrocyte membrane